Linked Life Data

7824549

Source:http://linkedlifedata.com/resource/pubmed/id/7824549

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-2-15
pubmed:abstractText
It has been suggested that stress during the initial stages of human life may serve as a predisposing factor to mental illness. Recently, we reported that in pregnant rats, stress induces an increase of behavioral depression in the female offsprings when adult. This article describes the effect of prenatal stress on central dopaminergic transmission during adulthood. The offspring of stressed mothers showed an increase of behavioral depression in the Porsolt test and a reduction of DOPAC, HVA, and DOPAC/DA index in the n. accumbens. The effect on the right accumbens was more marked than on the left. A great body of information exists to suggest that depression is related to a decrease of dopaminergic neurotransmission, and the present data provide new evidence in support of the hypothesis that maternal stress during gestation increases the risk of depression in the offspring. We are also reporting a hitherto uncommented relationship between behavioral depression in the Porsolt test and the decrease of dopamine transmission in the n. accumbens.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
353-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Permanent dopaminergic alterations in the n. accumbens after prenatal stress.
pubmed:affiliation
Department of Pharmacology, Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain.
pubmed:publicationType
Journal Article