Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1995-2-13
|
| pubmed:abstractText |
Salivary polymorphonuclear leukocyte (SPMN) functions were examined in 18 patients with oral squamous cell carcinoma and in 20 healthy individuals. SPMN obtained from patients before therapy exhibited significantly less FMLP-stimulated chemotactic activity (132.4 +/- 17.5 cells/0.26 mm2) than that in SPMN from controls (177.1 +/- 11.6 cells/0.26 mm2), although no difference in phagocytosis was observed. When stimulated with PMA or FMLP, control SPMN generated superoxide (O2-) at levels of 50.3 +/- 10.5 pmol/min/10(4) cells and 88.4 +/- 15.4 pmol, respectively, while SPMN from untreated patients generated significantly reduced O2- in the presence of PMA or FMLP (24.3 +/- 3.5 pmol and 59.5 +/- 9.8 pmol, respectively). Only slightly lower chemiluminescence was observed in SPMN from untreated patients however, compared to controls, values being 68.0 +/- 18.9 vs 81.3 +/- 14.9 peak mV by PMA and 62.4 +/- 13.7 vs 64.4 +/- 12.9 peak mV by FMLP. Compared to Candida killing in control subjects (24.9 +/- 3.1%). SPMN from patients before treatment exhibited significantly reduced activity (18.7 +/- 4.9%). Further suppression of the SPMN functions examined was observed after chemoradio-therapy. Suppressed SPMN function in cancer patients, especially that associated with chemoradiotherapy, may therefore play a part in oral candidiasis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
D
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0904-2512
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
23
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
418-22
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7823303-Adult,
pubmed-meshheading:7823303-Aged,
pubmed-meshheading:7823303-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:7823303-Candidiasis, Oral,
pubmed-meshheading:7823303-Carcinoma, Squamous Cell,
pubmed-meshheading:7823303-Case-Control Studies,
pubmed-meshheading:7823303-Chemotaxis, Leukocyte,
pubmed-meshheading:7823303-Cobalt Radioisotopes,
pubmed-meshheading:7823303-Combined Modality Therapy,
pubmed-meshheading:7823303-Cranial Irradiation,
pubmed-meshheading:7823303-Cytotoxicity, Immunologic,
pubmed-meshheading:7823303-Female,
pubmed-meshheading:7823303-Fluorouracil,
pubmed-meshheading:7823303-Humans,
pubmed-meshheading:7823303-Leukocyte Count,
pubmed-meshheading:7823303-Luminescent Measurements,
pubmed-meshheading:7823303-Male,
pubmed-meshheading:7823303-Middle Aged,
pubmed-meshheading:7823303-Mouth Neoplasms,
pubmed-meshheading:7823303-Neutrophils,
pubmed-meshheading:7823303-Peplomycin,
pubmed-meshheading:7823303-Phagocytosis,
pubmed-meshheading:7823303-Remission Induction,
pubmed-meshheading:7823303-Respiratory Burst,
pubmed-meshheading:7823303-Saliva,
pubmed-meshheading:7823303-Superoxides
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Influence of inductive chemoradiotherapy on salivary polymorphonuclear leukocyte (SPMN) functions in oral cancer.
|
| pubmed:affiliation |
Department of Oral Surgery, Kochi Medical School, Kohasu, Japan.
|
| pubmed:publicationType |
Journal Article
|