Linked Life Data

7822940

Source:http://linkedlifedata.com/resource/pubmed/id/7822940

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-2-15
pubmed:abstractText
In 10 conscious, chronically instrumented beagle dogs we studied the effects of four different dietary sodium intakes (mmol Na/kg body wt/day: 14.5 [excess], 7.5 [high], 2.5 [normal], and 0.5 [low] [plus an additional standardized sodium depletion produced by peritoneal dialysis several days before the experiments]) on cardiac baroreflex sensitivity and renal response to an acute saline load. Full sigmoid barocurves were produced by intravenous injection of phenylephrine (2.5 to 20 micrograms/kg) and nitroglycerine (2.5 to 30 micrograms/kg). The gain of this relationship was significantly decreased by both an excess and low sodium intake (8.0 +/- 1.0 and 8.3 +/- 0.8 beats/min/mm Hg, respectively) when compared with the 2.5 and 7.5 (12.1 +/- 1.4 and 16.0 +/- 1.7 beats/min/mm Hg, respectively) mmol Na/kg/day sodium intake. Water and sodium excretion in response to saline infusion were lower in the 0.5 and 14.5 mmol/kg/day sodium intake groups in spite of the higher atrial natriuretic peptide and lower plasma renin activity and plasma aldosterone levels in the latter. Mean arterial blood pressure, heart rate, and central venous pressure increased during saline loading in all groups; hematocrit and plasma protein concentration decreased similarly in all groups. The results suggest that the rapid renal homeostatic response to an acute salt load in animals kept chronically on normal or moderately increased dietary sodium intake is regulated by baroreflex control of the renal homeostatic response. Excess dietary sodium intake attenuates baroreflex sensitivity and delays sodium and water excretion after acute loading.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-2143
pubmed:author
pubmed:issnType
Print
pubmed:volume
125
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
120-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Cardiac baroreflex sensitivity and sodium excretion are reduced both by a deficit and an excess of dietary salt in the conscious dog.
pubmed:affiliation
AG Experimentelle Anästhesie, UKRV-Charlottenburg, Freie Universität Berlin, Germany.
pubmed:publicationType
Journal Article