| pubmed-article:7822795 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7822795 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7822795 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:7822795 | lifeskim:mentions | umls-concept:C0008633 | lld:lifeskim |
| pubmed-article:7822795 | lifeskim:mentions | umls-concept:C0033681 | lld:lifeskim |
| pubmed-article:7822795 | lifeskim:mentions | umls-concept:C0009017 | lld:lifeskim |
| pubmed-article:7822795 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:7822795 | lifeskim:mentions | umls-concept:C0445223 | lld:lifeskim |
| pubmed-article:7822795 | lifeskim:mentions | umls-concept:C1552599 | lld:lifeskim |
| pubmed-article:7822795 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:7822795 | lifeskim:mentions | umls-concept:C1704787 | lld:lifeskim |
| pubmed-article:7822795 | lifeskim:mentions | umls-concept:C1518071 | lld:lifeskim |
| pubmed-article:7822795 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:7822795 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7822795 | pubmed:dateCreated | 1995-2-16 | lld:pubmed |
| pubmed-article:7822795 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7822795 | pubmed:abstractText | Triggering of Ag receptors on lymphocytes induces rapid phosphorylation of several receptor-associated protein tyrosine kinases (PTKs), implicating their role in controlling cellular growth and differentiation. In this study, we report the cloning of a human cDNA encoding a nonreceptor PTK with a calculated M(r) of about 58 kDa. The kinase has an overall amino acid identity of approximately 87% with the murine Blk. However, in the unique domain there is only 58% homology and an insertion of six amino acids in the N-terminal region. The nature of this insertion suggests a functional role in membrane attachment. Northern blot analysis showed expression in all stages of B cell development and in T cell lines. The message was not observed in the nonlymphoid tissues examined. In contrast, expression of murine blk in plasma cells and T lymphocytes has not been reported. Importantly, transcripts were seen in human embryonic liver as early as 7.5 wk of gestation before the rearrangement of Ig H chain locus. Furthermore, transcripts were detected in human thymocytes and not in mature T cells. Southern blot analysis revealed polymorphism of this gene in a Caucasian population but not in a Gambian population, indicating a recent origin of this polymorphism. The gene was localized to chromosome 8p22-23. The homology at the protein level suggests that this kinase may be the human homologue of murine Blk. Expression of BLK in immature T cells suggests that BLK may play an important role in thymopoiesis. | lld:pubmed |
| pubmed-article:7822795 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7822795 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7822795 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7822795 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7822795 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7822795 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7822795 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7822795 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:7822795 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:7822795 | pubmed:author | pubmed-author:LarssonCC | lld:pubmed |
| pubmed-article:7822795 | pubmed:author | pubmed-author:SmithC ICI | lld:pubmed |
| pubmed-article:7822795 | pubmed:author | pubmed-author:RabbaniHH | lld:pubmed |
| pubmed-article:7822795 | pubmed:author | pubmed-author:SandersRR | lld:pubmed |
| pubmed-article:7822795 | pubmed:author | pubmed-author:IslamK BKB | lld:pubmed |
| pubmed-article:7822795 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7822795 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7822795 | pubmed:volume | 154 | lld:pubmed |
| pubmed-article:7822795 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7822795 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7822795 | pubmed:pagination | 1265-72 | lld:pubmed |
| pubmed-article:7822795 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:7822795 | pubmed:meshHeading | pubmed-meshheading:7822795-... | lld:pubmed |
| pubmed-article:7822795 | pubmed:meshHeading | pubmed-meshheading:7822795-... | lld:pubmed |
| pubmed-article:7822795 | pubmed:meshHeading | pubmed-meshheading:7822795-... | lld:pubmed |
| pubmed-article:7822795 | pubmed:meshHeading | pubmed-meshheading:7822795-... | lld:pubmed |
| pubmed-article:7822795 | pubmed:meshHeading | pubmed-meshheading:7822795-... | lld:pubmed |
| pubmed-article:7822795 | pubmed:meshHeading | pubmed-meshheading:7822795-... | lld:pubmed |
| pubmed-article:7822795 | pubmed:meshHeading | pubmed-meshheading:7822795-... | lld:pubmed |
| pubmed-article:7822795 | pubmed:meshHeading | pubmed-meshheading:7822795-... | lld:pubmed |
| pubmed-article:7822795 | pubmed:meshHeading | pubmed-meshheading:7822795-... | lld:pubmed |
| pubmed-article:7822795 | pubmed:meshHeading | pubmed-meshheading:7822795-... | lld:pubmed |
| pubmed-article:7822795 | pubmed:meshHeading | pubmed-meshheading:7822795-... | lld:pubmed |
| pubmed-article:7822795 | pubmed:meshHeading | pubmed-meshheading:7822795-... | lld:pubmed |
| pubmed-article:7822795 | pubmed:meshHeading | pubmed-meshheading:7822795-... | lld:pubmed |
| pubmed-article:7822795 | pubmed:meshHeading | pubmed-meshheading:7822795-... | lld:pubmed |
| pubmed-article:7822795 | pubmed:meshHeading | pubmed-meshheading:7822795-... | lld:pubmed |
| pubmed-article:7822795 | pubmed:meshHeading | pubmed-meshheading:7822795-... | lld:pubmed |
| pubmed-article:7822795 | pubmed:meshHeading | pubmed-meshheading:7822795-... | lld:pubmed |
| pubmed-article:7822795 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7822795 | pubmed:articleTitle | Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk. | lld:pubmed |
| pubmed-article:7822795 | pubmed:affiliation | Center for BioTechnology, Karolinska Institute, NOVUM, Huddinge, Sweden. | lld:pubmed |
| pubmed-article:7822795 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7822795 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:640 | entrezgene:pubmed | pubmed-article:7822795 | lld:entrezgene |
| entrez-gene:12143 | entrezgene:pubmed | pubmed-article:7822795 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7822795 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7822795 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7822795 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7822795 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7822795 | lld:pubmed |
