Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-2-16
pubmed:abstractText
The major merozoite surface protein of Plasmodium falciparum (PfMSP1) is a candidate antigen for a malaria vaccine. A 19-kDa C-terminal processing product of PfMSP1 (PfMSP1(19)) is composed of two domains sharing a cysteine-rich motif with epidermal growth factor (EGF) and is the target of monoclonal antibodies which block erythrocyte invasion in vitro. We have evaluated human antibody responses to PfMSP1(19) by using recombinant proteins representing the EGF motifs encoded by the two main alleles of the MSP1 gene. We find that both EGF motifs are antigenic but that only 10 to 20% of malaria-exposed individuals have serum antibodies that recognized either of the motifs. When both EGF motifs were expressed together as a single protein, they were recognized by more than 40% of sera from malaria-exposed individuals. Major epitopes recognized by human antibodies are dependent upon the correct tertiary structure of the protein and are cross-reactive between the different allelic sequences of PfMSP1(19). This suggests that antibodies induced by vaccination with one or the other allelic forms of the protein could recognize all strains of P. falciparum. Immunoglobulin G (IgG) subclass-specific enzyme immunoassays indicate that PfMSP1(19) antibodies are predominantly of the IgG1 subclass.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-1574088, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-1613259, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-1624802, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-1625908, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-1694225, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-1723148, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-1741018, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-1775158, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-1894356, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-2187200, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-2416867, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-2437453, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-2448732, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-2467942, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-2995820, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-3047011, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-3302727, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-3318021, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-3495735, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-3534885, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-3554251, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-3881529, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-6090934, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-6201740, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-6355363, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-6374450, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-6381635, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-6381636, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-7516493, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-7694147, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-8015856, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-8078519, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-8363656, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-8515771, http://linkedlifedata.com/resource/pubmed/commentcorrection/7822010-8515786
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
456-66
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:7822010-Humans, pubmed-meshheading:7822010-Age Factors, pubmed-meshheading:7822010-Animals, pubmed-meshheading:7822010-Adolescent, pubmed-meshheading:7822010-Infant, pubmed-meshheading:7822010-Aged, pubmed-meshheading:7822010-Child, pubmed-meshheading:7822010-Disulfides, pubmed-meshheading:7822010-Child, Preschool, pubmed-meshheading:7822010-Plasmodium falciparum, pubmed-meshheading:7822010-Adult, pubmed-meshheading:7822010-Malaria, Falciparum, pubmed-meshheading:7822010-Middle Aged, pubmed-meshheading:7822010-Amino Acid Sequence, pubmed-meshheading:7822010-Immunoglobulin G, pubmed-meshheading:7822010-Alleles, pubmed-meshheading:7822010-Molecular Sequence Data, pubmed-meshheading:7822010-Protozoan Proteins, pubmed-meshheading:7822010-Cross Reactions, pubmed-meshheading:7822010-Antibodies, Protozoan
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