Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1976-9-25
pubmed:abstractText
The evidence suggests that glucose transport across the blood brain barrier (BBB) in the dog is normally not a rate-limiting step in cerebral metabolism; however, transport may become rate-limiting under conditions of extreme hypoglycemia or anoxia. Studies on the mechanism of glucose transport from blood to brain do not at this time permit us to distinguish between active transport and facilitated diffusion; however, a decrease in the rate of unidirectional transport during anoxia suggests that an energy-dependent process may be involved. In spite of this evidence, glucose transport across the BBB is similar to the facilitated diffusion of glucose into the red cell in terms of the structural requirements of the glucose molecule, the pattern of inhibition by phlorizin, phloretin and cytochalasin B, and the lack of sensitivity to Na+ or insulin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-2598
pubmed:author
pubmed:issnType
Print
pubmed:volume
69
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
133-49
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:782188-Animals, pubmed-meshheading:782188-Anoxia, pubmed-meshheading:782188-Biological Transport, Active, pubmed-meshheading:782188-Blood Glucose, pubmed-meshheading:782188-Blood-Brain Barrier, pubmed-meshheading:782188-Brain, pubmed-meshheading:782188-Capillaries, pubmed-meshheading:782188-Cytochalasin B, pubmed-meshheading:782188-Dogs, pubmed-meshheading:782188-Endothelium, pubmed-meshheading:782188-Erythrocytes, pubmed-meshheading:782188-Glucose, pubmed-meshheading:782188-Humans, pubmed-meshheading:782188-Hypoglycemia, pubmed-meshheading:782188-Kinetics, pubmed-meshheading:782188-Methylglucosides, pubmed-meshheading:782188-Models, Biological, pubmed-meshheading:782188-Monosaccharides, pubmed-meshheading:782188-Phloretin, pubmed-meshheading:782188-Phlorhizin, pubmed-meshheading:782188-Structure-Activity Relationship
pubmed:year
1976
pubmed:articleTitle
The characteristics of glucose transport across the blood brain barrier and its relation to cerebral glucose metabolism.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review