Linked Life Data

7821708

Source:http://linkedlifedata.com/resource/pubmed/id/7821708

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-2-16
pubmed:abstractText
The gene expression of four fibroblast growth factor receptors (flg, bek, FGFR-3, and FGFR-4) in rat ovary cells was studied. Northern blot hybridization revealed that flg and bek mRNAs were detectable during all stages except a diestrus stage, whereas FGFR-3 and FGFR-4 mRNAs were almost undetectable throughout the cycles. In situ hybridization also demonstrated that only flg and bek gene expression was detectable. A modest flg mRNA signal was detected in developing antral follicles and it was more prominent in the theca-interstitial cells than in the granulosa cells. A modest to weak flg mRNA signal was seen in the hypertrophied theca-interstitial cells of atretic follicles and a very weak flg mRNA signal was observed in the corpora lutea. On the other hand, a weak bek mRNA signal was seen in granulosa and theca-interstitial cells in developing follicles and also hypertrophied theca-interstitial cells of atretic follicles, but not in the corpora lutea. Intense signals for both flg and bek mRNAs were unexpectedly found in the epithelium of paroophoron at the hilus. These results demonstrate that the bFGF receptor isoforms are expressed differentially in the rat ovary cells.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0303-7207
pubmed:author
pubmed:issnType
Print
pubmed:volume
104
pubmed:geneSymbol
FGFR-3, FGFR-4, bek, flg
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
75-80
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:7821708-Animals, pubmed-meshheading:7821708-Blotting, Northern, pubmed-meshheading:7821708-Female, pubmed-meshheading:7821708-Gene Expression Regulation, pubmed-meshheading:7821708-In Situ Hybridization, pubmed-meshheading:7821708-Isomerism, pubmed-meshheading:7821708-Ovary, pubmed-meshheading:7821708-Protein-Tyrosine Kinases, pubmed-meshheading:7821708-RNA, Messenger, pubmed-meshheading:7821708-Rats, pubmed-meshheading:7821708-Rats, Sprague-Dawley, pubmed-meshheading:7821708-Receptor, Fibroblast Growth Factor, Type 2, pubmed-meshheading:7821708-Receptor, Fibroblast Growth Factor, Type 3, pubmed-meshheading:7821708-Receptor, Fibroblast Growth Factor, Type 4, pubmed-meshheading:7821708-Receptor Protein-Tyrosine Kinases, pubmed-meshheading:7821708-Receptors, Fibroblast Growth Factor
pubmed:year
1994
pubmed:articleTitle
Differential gene expression of fibroblast growth factor receptor isoforms in rat ovary.
pubmed:affiliation
Division of Functional Disorder Research, Tokyo Medical & Dental University, Japan.
pubmed:publicationType
Journal Article