Linked Life Data

7819451

Source:http://linkedlifedata.com/resource/pubmed/id/7819451

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-2-13
pubmed:abstractText
The Ped (preimplantation embryo development) gene, which maps to the Q region of the mouse major histocompatibility complex (MHC), controls the rate of cleavage division of preimplantation mouse embryos and subsequent embryonic survival. Of the ten known MHC class I genes in the Q region of the mouse MHC, four--Q6, Q7, Q8, and Q9--are almost identical and encode similar proteins, all called the Qa-2 antigen. Previous studies have suggested that the Q9 gene encodes the Ped gene. To test this directly, one-cell embryos from the CBA/Ca strain (Ped slow) that is missing the Q9 gene and the Qa-2 antigen were injected with the Q9 gene from the C57BL/10 strain (Ped fast) that possesses the Q9 gene and expresses the Qa-2 antigen. The resulting Q9 transgenic mice were found to express the Qa-2 antigen. In addition, it was found that introduction of the Q9 gene converted the Ped gene phenotype of the recipient strain from slow to fast. Therefore, the Ped gene product is the Qa-2 antigen encoded by the Q9 gene.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0006-3363
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:geneSymbol
Ped, Q9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
695-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Identification of the Ped gene at the molecular level: the Q9 MHC class I transgene converts the Ped slow to the Ped fast phenotype.
pubmed:affiliation
Department of Biology, Northeastern University, Boston, Massachusetts 02115.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.