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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1995-2-14
|
| pubmed:abstractText |
We report here the x-ray studies of the complex cytosolic aspartate aminotransferase from chicken heart with D-aspartate at 2,7 A resolution. Crystals of the complex was prepared by diffusing D-aspartate into free enzyme crystals; their space group is P 2(1)2(1)2(1) with cell dimensions (A): a = 62.59; b = 117.83; c = 124.38. They contain one dimeric molecule in the asymmetric unit. The x-ray crystallographic analysis proves that the connection of the D-aspartate induces small conformational changes in the active site of two subunits of the enzyme: considerable conformational changes are determined for His 189, Phe 360, Tyr 70, Arg 292, Phe 18 and Glu 141.
|
| pubmed:language |
rus
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0006-3029
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
39
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
761-5
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7819305-Animals,
pubmed-meshheading:7819305-Aspartate Aminotransferases,
pubmed-meshheading:7819305-Aspartic Acid,
pubmed-meshheading:7819305-Binding Sites,
pubmed-meshheading:7819305-Chickens,
pubmed-meshheading:7819305-Crystallography, X-Ray,
pubmed-meshheading:7819305-Myocardium,
pubmed-meshheading:7819305-Protein Conformation
|
| pubmed:articleTitle |
[The complex of aspartate aminotransferase with D-aspartate].
|
| pubmed:publicationType |
Journal Article,
English Abstract
|