Linked Life Data

7817804

Source:http://linkedlifedata.com/resource/pubmed/id/7817804

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1995-2-6
pubmed:abstractText
Effects of calcitonin peptides, including human calcitonin (hCT), salmon calcitonin (sCT), and calcitonin gene-related peptide (CGRP), on the secretion of testosterone and luteinizing hormone (LH) in male rats were studied. Male rats were injected intravenously with human chorionic gonadotropin (hCG), calcitonin peptides, or hCG plus calcitonin peptides. Blood samples were collected at several intervals following hormone challenge. In an in vitro experiment, testis blocks were incubated with hCG (0, 0.05, 0.5, or 5 IU/ml) or hCG (0.5 IU/ml) plus calcitonin peptides (0-10(-9) or 10(-6) M) at 34 degrees C for 30 minutes. Both medium and plasma samples were extracted by ether and analyzed for testosterone by radioimmunoassay (RIA). The concentration of calcium in each plasma sample was measured by an automatic calcium analyzer. The anterior pituitary gland (AP) was incubated with or without calcitonin peptides (0-10 nM) at 37 degrees C for 30 minutes. They were then incubated with gonadotropin releasing hormone (GnRH, 10 nM) for a further 30 minutes. The concentration of LH in AP medium was measured by RIA. The accumulation of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in both testicular tissues and APs were measured by RIA. A single intravenous injection of calcitonin peptides decreased the basal and hCG-stimulated levels of plasma testosterone gradually from 60 to 180 or 360 minutes after challenge. The plasma calcium was not altered by the injection of calcitonin peptides and/or hCG. Administration of calcitonin peptides in vitro resulted in a dose-dependent inhibition of both basal and hCG-stimulated release of testosterone.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0884-0431
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
1583-90
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:7817804-Analysis of Variance, pubmed-meshheading:7817804-Animals, pubmed-meshheading:7817804-Calcitonin, pubmed-meshheading:7817804-Calcitonin Gene-Related Peptide, pubmed-meshheading:7817804-Calcium, pubmed-meshheading:7817804-Chorionic Gonadotropin, pubmed-meshheading:7817804-Cyclic AMP, pubmed-meshheading:7817804-Cyclic GMP, pubmed-meshheading:7817804-Dose-Response Relationship, Drug, pubmed-meshheading:7817804-Humans, pubmed-meshheading:7817804-Injections, Intravenous, pubmed-meshheading:7817804-Luteinizing Hormone, pubmed-meshheading:7817804-Male, pubmed-meshheading:7817804-Pituitary Gland, Anterior, pubmed-meshheading:7817804-Radioimmunoassay, pubmed-meshheading:7817804-Rats, pubmed-meshheading:7817804-Rats, Sprague-Dawley, pubmed-meshheading:7817804-Testis, pubmed-meshheading:7817804-Testosterone
pubmed:year
1994
pubmed:articleTitle
Calcitonin inhibits testosterone and luteinizing hormone secretion through a mechanism involving an increase in cAMP production in rats.
pubmed:affiliation
Department of Physiology, National Yang-Ming University, Taipei, Taiwan, Republic of China.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't