Linked Life Data

7816963

Source:http://linkedlifedata.com/resource/pubmed/id/7816963

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1995-2-6
pubmed:abstractText
Hui and Walter proposed an approach to directly estimate the parameters of diagnostic tests (sensitivity and specificity for dichotomous tests) and the prevalence of the disease in the absence of a reference error-free test, and without imposing any constraint. We performed a simulation study to investigate the finite-sample properties of the proposed estimators for the situation of three tests. We obtained the following results: i) in screening situations (prevalence < or = 0.10), severe bias and poor precision in the parameter estimates occur and this approach should not be used except for studies with a very large sample size (n > or = 2500); ii) in diagnostic situations (prevalence > or = 0.30), the approach is much more reliable and very little or no bias occurs even for small sample sizes (n = 50, 100), except when both the prevalence is very high (p > or = 0.90) and the performances of the tests mediocre (sensitivity and specificity lower than 0.80).
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0398-7620
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
502-11
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
[Estimation by the Hui and Walter method of the sensitivity and specificity of a diagnostic test in the absence of a reference test: results of a simulation study].
pubmed:affiliation
Laboratoire de Biostatistique et Informatique Médicale, Hôpital Bretonneau, CHU Tours.
pubmed:publicationType
Journal Article, Comparative Study, English Abstract, Research Support, Non-U.S. Gov't