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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1995-2-8
|
| pubmed:abstractText |
Loss of renal functional reserve, that is, absence of the glomerular vasodilatory response to amino-acid infusion, has been interpreted as equivalent to glomerular hyperperfusion/hypertension, and therefore proposed as a marker of high risk for progressive glomerular sclerosis. To substantiate the validity of this hypothesis we evaluated the renal response to glycine and the extent of glomerular damage 10-12 weeks after induction of anti-glomerular basement membrane glomerulonephritis with or without superimposed clip hypertension. Untreated rats and rats chronically treated with quinapril, a converting-enzyme inhibitor, were studied. In untreated groups, loss of renal functional reserve was demonstrated since GFR, single-nephron GFR (SNGFR) and plasma flow (SNPF) did not increase during glycine infusion. The absence of renal reserve was associated with glomerular hyperfusion/hypertension, and development of proteinuria and glomerulosclerosis. Quinapril reduced proteinuria and diffuse sclerosis in anti-glomerular basement membrane GN, and decreased blood pressure and segmental glomerulosclerosis in antiglomerular basement membrane GN with superimposed clip hypertension. Both treated groups demonstrated a restoration of renal functional reserve, as depicted by increases in GFR, SNGFR, and SNPF after glycine, despite persistence of glomerular hyperperfusion/hypertension. These data demonstrate that renal functional reserve testing, although it does not detect glomerular hyperperfusion/hypertension, can provide information on the progression of glomerular damage.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin-Converting Enzyme...,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Antihypertensive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Glycine,
http://linkedlifedata.com/resource/pubmed/chemical/Isoquinolines,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrahydroisoquinolines,
http://linkedlifedata.com/resource/pubmed/chemical/quinapril
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0931-0509
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1383-9
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:7816249-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:7816249-Animals,
pubmed-meshheading:7816249-Antibodies,
pubmed-meshheading:7816249-Antihypertensive Agents,
pubmed-meshheading:7816249-Basement Membrane,
pubmed-meshheading:7816249-Chronic Disease,
pubmed-meshheading:7816249-Glomerulonephritis,
pubmed-meshheading:7816249-Glycine,
pubmed-meshheading:7816249-Hypertension, Renovascular,
pubmed-meshheading:7816249-Isoquinolines,
pubmed-meshheading:7816249-Kidney,
pubmed-meshheading:7816249-Kidney Function Tests,
pubmed-meshheading:7816249-Kidney Glomerulus,
pubmed-meshheading:7816249-Kidney Tubules,
pubmed-meshheading:7816249-Male,
pubmed-meshheading:7816249-Rats,
pubmed-meshheading:7816249-Rats, Wistar,
pubmed-meshheading:7816249-Renal Circulation,
pubmed-meshheading:7816249-Tetrahydroisoquinolines
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Renal functional reserve in experimental chronic glomerulonephritis.
|
| pubmed:affiliation |
Division of Nephrology-Hypertension, University of California, San Diego School of Medicine.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|