Linked Life Data

7815676

Source:http://linkedlifedata.com/resource/pubmed/id/7815676

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1995-2-8
pubmed:abstractText
To investigate whether increased availability of lipids affects glucose metabolism in healthy postabsorptive men when lipid and glucose are infused in amounts used in parenteral nutrition, we infused glucose (4 mg/kg.min-1) for 6 hours and clamped plasma glucose at basal level during the first 3 hours. After 3 hours, either long-chain triglycerides (LCTs) (0.07 g/kg.h-1) (n = 7) or a mixture of LCTs and medium-chain triglycerides (MCTs) (MCTs/LCTs, 50/50%, 0.07 g/kg.h-1) (n = 7) was administered, and the infusion rates of glucose and insulin were unchanged compared with the first 3 hours. In a control study, glucose was infused for a period of 6 hours without the lipid infusion (n = 5). After 6 hours, the plasma glucose concentration and glucose tissue uptake were not affected by LCT or MCT/LCT infusion. Nonetheless, glucose oxidation decreased in the LCT group (from 6.42 +/- 1.04 to 2.31 +/- 0.85 mumol/kg.min-1, p < .001) and in the MCT/LCT group (from 7.62 +/- 1.50 to 5.50 +/- 0.76 mumol/kg.min-1, p < .01) but not in the control group. Concentrations of the glucoregulatory hormones were not different among the three groups. In conclusion, MCTs/LCTs administered concomitantly with glucose infusion, in amounts similar to those used in total parenteral nutrition, inhibit glucose oxidation without affecting glucose tissue uptake, just as LCTs do.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0148-6071
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
436-41
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:articleTitle
Infusion of long-chain or medium-chain triglycerides inhibits peripheral glucose metabolism in men.
pubmed:affiliation
Department of Internal Medicine, University of Amsterdam, The Netherlands.
pubmed:publicationType
Journal Article, Clinical Trial, Controlled Clinical Trial