Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-2-9
pubmed:abstractText
The effects of a continuous infusion of a calcium entry blocker, 1, 5-benzothiazepine derivative (diltiazem), on ischemic liver cell damage were studied using quantitative 45Ca-autoradiographic and liquid scintillation techniques. The drug was administered to male Wistar rats as a continuous infusion for 3 h, beginning 30 min before ischemia. Autoradiographic studies showed that 45Ca accumulated in the liver lobuli after 1 h of liver ischemia and 3 h of reperfusion, but the level of 45Ca accumulation was significantly lower in drug-treated rats than in untreated animals. In addition, liquid scintillation studies showed significant differences in the intrahepatic 45Ca contents. These results suggest that diltiazem may inhibit the rise of intracellular Ca2+ due to the flow of extracellular Ca2+ into the cytosol, and may protect the ischemic liver from damage.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0168-8278
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
567-71
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Inhibition of the increase of intrahepatic Ca2+ by diltiazem in rats with liver ischemia.
pubmed:affiliation
First Department of Surgery, Kagoshima University, School of Medicine, Japan.
pubmed:publicationType
Journal Article