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pubmed-article:7814689pubmed:abstractTextIn order to establish the specificity of growth and termination of dorsal root afferents within the developing spinal cord, the central dorsal horn terminals of myelinated sensory afferents were labelled at various stages in the rat from embryonic day (E)18 through to postnatal day (P) 35 using horseradish peroxidase conjugated to choleragenoid (B-HRP). The preferential labelling of A fibre afferents with this tracer was found to be as clear in the neonate as has been reported for the adult. The results show that while the somatotopic arrangement of A fibre afferent terminals in the dorsal horn is established early in development, the laminar projections are not. Following peripheral nerve or local skin injections of B-HRP, A fibre terminals were found to project throughout laminae I to V, including lamina II (substantia gelatinosa). This widespread termination was observed consistently until the end of the third postnatal week. After P22 the terminal field becomes restricted to the normal laminae III to V.lld:pubmed
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pubmed-article:7814689pubmed:articleTitleDevelopmental changes in the laminar termination of A fibre cutaneous sensory afferents in the rat spinal cord dorsal horn.lld:pubmed
pubmed-article:7814689pubmed:affiliationDepartment of Anatomy and Developmental Biology, University College London, United Kingdom.lld:pubmed
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