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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0022116,
umls-concept:C0027950,
umls-concept:C0033684,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0035820,
umls-concept:C0185117,
umls-concept:C0205054,
umls-concept:C0221908,
umls-concept:C0273115,
umls-concept:C0282554,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
1995-2-9
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pubmed:abstractText |
The liver is highly susceptible to a number of pathological insults, including ischemia/reperfusion injury. One of the striking consequences of liver injury is the associated pulmonary dysfunction that may be related to the release of hepatic-derived cytokines. We have previously employed an animal model of hepatic ischemia/reperfusion injury, and demonstrated that this injury causes the production and release of hepatic-derived TNF, which mediates a neutrophil-dependent pulmonary microvascular injury. In this study, we have extended these previous observations to assess whether an interrelationship between TNF and the neutrophil chemoattractant/activating factor, epithelial neutrophil activating protein-78 (ENA-78), exists that may be accountable for the pathology of lung injury found in this model. In the context of hepatic ischemia/reperfusion injury, we demonstrated the following alterations in lung pathophysiology: (a) an increase in pulmonary microvascular permeability, lung neutrophil sequestration, and production of pulmonary-derived ENA-78; (b) passive immunization with neutralizing TNF antiserum resulted in a significant suppression of pulmonary-derived ENA-78; and (c) passive immunization with neutralizing ENA-78 antiserum resulted in a significant attenuation of pulmonary neutrophil sequestration and microvascular permeability similar to our previous studies with anti-TNF. These findings support the notion that pulmonary ENA-78 produced in response to hepatic-derived TNF is an important mediator of lung injury.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-1428026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-1650020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-1744577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-1968349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-1974032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-2123991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-2159035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-2161433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-2182081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-2305455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-2491503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-2677047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-2970963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-3001018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-3059888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-3202118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-3276800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-3298433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-3484794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-3643211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-3661679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-6088654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-6325501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-6361134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-6620431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-6876872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-7460207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-8153928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-8496676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7814607-872835
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
134-41
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7814607-Animals,
pubmed-meshheading:7814607-Base Sequence,
pubmed-meshheading:7814607-Capillary Permeability,
pubmed-meshheading:7814607-Chemokine CXCL5,
pubmed-meshheading:7814607-Chemokines, CXC,
pubmed-meshheading:7814607-Immunohistochemistry,
pubmed-meshheading:7814607-Interleukin-8,
pubmed-meshheading:7814607-Liver,
pubmed-meshheading:7814607-Lung,
pubmed-meshheading:7814607-Male,
pubmed-meshheading:7814607-Microcirculation,
pubmed-meshheading:7814607-Molecular Sequence Data,
pubmed-meshheading:7814607-Neutrophils,
pubmed-meshheading:7814607-RNA, Messenger,
pubmed-meshheading:7814607-Rats,
pubmed-meshheading:7814607-Rats, Sprague-Dawley,
pubmed-meshheading:7814607-Reperfusion Injury
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pubmed:year |
1995
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pubmed:articleTitle |
Chemokine expression during hepatic ischemia/reperfusion-induced lung injury in the rat. The role of epithelial neutrophil activating protein.
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pubmed:affiliation |
Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor 48109-0360.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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