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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1995-2-3
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pubmed:abstractText |
The effect of peripheral sensory deprivation upon GABAA receptor binding of [3H]muscimol was investigated in the barrel cortex--cortical representation of mystacial vibrissae of mice--by means of in vitro quantitative autoradiography. Unilateral lesions of all vibrissae or selected rows of whiskers were performed neonatally or in adulthood. [3H]muscimol binding was examined after various survival times up to 60 days. Both types of lesions performed in adult mice resulted in a transient decrease (10-25%) of binding values in the deafferented areas of the barrel field as compared with the unoperated control side. Sixty days after denervation [3H]muscimol binding returned to control values. Similar results were found after neonatal removal of all vibrissae. Neonatal lesion of selected rows of vibrissae, however, resulted in a decrease of [3H]muscimol binding (by about 26%) lasting up to 60 days in corresponding rows of barrels. This last result was accompanied by severe cytoarchitectonic malformation of the barrel field. The results support the hypothesis that a decrease of inhibition plays a facilitatory role in the plastic reorganization of cortical circuitry.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0014-4819
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
100
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
39-46
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pubmed:dateRevised |
2009-11-11
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pubmed:meshHeading |
pubmed-meshheading:7813651-Aging,
pubmed-meshheading:7813651-Animals,
pubmed-meshheading:7813651-Animals, Newborn,
pubmed-meshheading:7813651-Autoradiography,
pubmed-meshheading:7813651-Cerebral Cortex,
pubmed-meshheading:7813651-Denervation,
pubmed-meshheading:7813651-Mice,
pubmed-meshheading:7813651-Muscimol,
pubmed-meshheading:7813651-Neuronal Plasticity,
pubmed-meshheading:7813651-Neurons, Afferent,
pubmed-meshheading:7813651-Peripheral Nerves,
pubmed-meshheading:7813651-Receptors, GABA-A,
pubmed-meshheading:7813651-Vibrissae
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pubmed:year |
1994
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pubmed:articleTitle |
Reduction of GABAA receptor binding of [3H]muscimol in the barrel field of mice after peripheral denervation: transient and long-lasting effects.
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pubmed:affiliation |
Department of Neurophysiology, Nencki Institute of Experimental Biology, Warsaw, Poland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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