Linked Life Data

7813572

Source:http://linkedlifedata.com/resource/pubmed/id/7813572

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1995-2-8
pubmed:abstractText
The relative importance of extracellular Ca2+ influx and intracellular Ca2+ release for the vasoconstrictor response to Sgd 101/75 (4(2-imidazoline-amino)-2-methyl-indazol-chlorhydrate), an alpha 1-adrenoceptor agonist, was examined in perfused rabbit ear arteries. Sdg 101/75 induced a phasic and a tonic vasoconstrictor response in a concentration-dependent manner. It is a full agonist on the tonic response but a partial agonist on the phasic response. Nifedipine preferentially inhibited the tonic but not the phasic response to Sgd 101/75. Therefore, Sgd 101/75 appears to require both the intracellular Ca2+ release and extracellular Ca2+ influx for its phasic and tonic responses in rabbit ear arteries, respectively.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
262
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
185-8
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Effects of nifedipine on phasic and tonic vasoconstrictor responses to Sgd 101/75 in the isolated perfused rabbit ear artery.
pubmed:affiliation
DuPont Merck Pharmaceutical Company, Wilmington, DE 19880-0400.
pubmed:publicationType
Journal Article