Linked Life Data

7813047

Source:http://linkedlifedata.com/resource/pubmed/id/7813047

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-2-7
pubmed:abstractText
The expression of ALZ-50 immunoreactivity in the immature rat cortex was assessed using a variety of immunochemical techniques. The antigen recognized by ALZ-50 was isolated using immunoaffinity column chromatography. Unlike the ALZ-50-positive antigen found in the brains of people with Alzheimer's Disease (mol. wt. 68 kDa), the principal antigen expressed in the immature rat had a molecular weight of 56 kDa. The temporal expression of ALZ-50-positive antigens was determined with immunoblotting techniques. The expression of the 56 kDa protein appeared during the last prenatal week, increased to a peak during the second postnatal week and waned in the third postnatal week. Immunohistochemically, neonatal cortex contained many ALZ-50-positive neurons in the cortical subplate and the intermediate zone and a smattering of neurons in the cortical plate. The temporal expression of the ALZ-50-positive 56 kDa antigen was similar to that for fetal tau (tau-1); however, the principal protein identified by the anti-tau-1 antibody was considerably larger (being about 68-70 kDa). In contrast to ALZ-50, tau-1-immunoreactive elements were distributed in the subplate, the deep cortical plate, the intermediate zone and the subventricular zone. tau-1-positive axons passing through the superficial intermediate zone were conspicuous. Thus, the biochemical and anatomical evidence show that ALZ-50 and tau-1 recognize distinct proteins.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0165-3806
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
260-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Developmental expression of a 56 kDa protein isolated from rat neocortex.
pubmed:affiliation
Veterans Affairs Medical Center, Iowa City, IA 52246-2208.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.