| pubmed-article:7812962 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7812962 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:7812962 | lifeskim:mentions | umls-concept:C0140080 | lld:lifeskim |
| pubmed-article:7812962 | lifeskim:mentions | umls-concept:C0021665 | lld:lifeskim |
| pubmed-article:7812962 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7812962 | pubmed:dateCreated | 1995-2-3 | lld:pubmed |
| pubmed-article:7812962 | pubmed:abstractText | The interaction of insulin-like growth factors (IGF) with the IGF-I receptor promotes cell proliferation and survival. We examined the role of the IGF-I receptor as a possible direct inhibitor of apoptosis induced by the topoisomerase I inhibitor etoposide. When exposed to this agent, BALB/c 3T3 cells that constitutively overexpress the human IGF-I receptor (p6 cells) arrested in S phase and subsequently underwent apoptosis as determined by the appearance of a pre-G1 apoptotic peak when studied by flow cytometry and the characteristic internucleosomal fragmentation of DNA. The addition of IGF-I markedly inhibited etoposide-induced apoptosis in a concentration-dependent manner. IGF-I was not mitogenic in the presence of etoposide. IGF-I was less effective in preventing apoptosis in parental BALB/c 3T3 cells and had no effect on etoposide-induced cell killing of mouse embryo fibroblasts that have a targeted disruption of the IGF-I receptor gene. These results demonstrate an important role for the IGF-I receptor as an inhibitor of apoptosis, independent of its mitogenic actions. | lld:pubmed |
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| pubmed-article:7812962 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7812962 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7812962 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7812962 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7812962 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7812962 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7812962 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7812962 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:7812962 | pubmed:author | pubmed-author:BasergaRR | lld:pubmed |
| pubmed-article:7812962 | pubmed:author | pubmed-author:RubinRR | lld:pubmed |
| pubmed-article:7812962 | pubmed:author | pubmed-author:SellCC | lld:pubmed |
| pubmed-article:7812962 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7812962 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:7812962 | pubmed:volume | 55 | lld:pubmed |
| pubmed-article:7812962 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7812962 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7812962 | pubmed:pagination | 303-6 | lld:pubmed |
| pubmed-article:7812962 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:7812962 | pubmed:meshHeading | pubmed-meshheading:7812962-... | lld:pubmed |
| pubmed-article:7812962 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7812962 | pubmed:articleTitle | Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis. | lld:pubmed |
| pubmed-article:7812962 | pubmed:affiliation | Department of Pathology, Jefferson Medical College, Philadelphia, Pennsylvania 19107. | lld:pubmed |
| pubmed-article:7812962 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7812962 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7812962 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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