Linked Life Data

7812788

Source:http://linkedlifedata.com/resource/pubmed/id/7812788

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1995-2-6
pubmed:abstractText
We examined chronic epileptogenicity in the perforant path stimulation model of focal status epilepticus. After 24 h of perforant path stimulation, every stimulation elicited multiple population spike discharges, and this phenomenon persisted more than 2-3 months after stimulation. Short (10-100 ms) interstimulus interval-dependent paired-pulse inhibition was almost completely lost right after stimulation, but recovered progressively over the following month. Long (200-1000 ms) interstimulus interval-dependent paired-pulse inhibition decreased, and in spite of a partial recovery, remained significantly reduced 4 weeks after stimulation. Frequency-dependent paired-pulse inhibition was lost immediately after stimulation. One month later, inhibition at 2 Hz remained significantly reduced, although in individual rats recovery ranged from poor to complete. Input/output response curves showed increased population spike amplitude but no change of the slope of excitatory postsynaptic potentials. 3-4 weeks after stimulation, spontaneous generalized motor convulsions were observed in half of the stimulated rats. In all of the stimulated rats, the kindling phenomenon was significantly accelerated compared with non-stimulated controls, and class 5 convulsions were elicited in 3.3 +/- 1.0 trials in stimulated rats, against 11.0 +/- 2.5 trials in controls.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
655
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
33-44
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Chronic epileptogenicity following focal status epilepticus.
pubmed:affiliation
Epilepsy Research, Neurology Service (127), Veterans Affairs Medical Center, Sepulveda, CA 91343.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.