Linked Life Data

7810067

Source:http://linkedlifedata.com/resource/pubmed/id/7810067

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1995-1-30
pubmed:abstractText
Proliferation of rainbow trout head kidney leucocytes in response to the mitogen phytohaemagglutinin-P (PHA-P) was modulated in the presence of inhibitors of eicosanoid synthesis and by exogenous eicosanoids. The presence of indomethacin, a cyclooxygenase inhibitor, resulted in a stimulatory effect, whereas the presence of nordihydroguiaretic acid, a lipoxygenase inhibitor, resulted in an inhibitory effect on mitogenicity. The addition of prostaglandins and lipoxins was also found to be inhibitory, whilst the addition of leukotrienes was stimulatory. Some class/series effects of the eicosanoids were also apparent. Prostaglandin E2 was a more potent inhibitor than prostaglandin E3, and proliferation was more sensitive to the effects of leukotriene B4 than to leukotriene B5. Whilst PHA-P was able to directly induce the release of prostaglandins from head kidney leucocytes, it did not induce the release of lipoxygenase products.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0165-2427
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
367-78
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
The effect of eicosanoids on rainbow trout, Oncorhynchus mykiss, leucocyte proliferation.
pubmed:affiliation
Department of Zoology, University of Aberdeen, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't