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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
26
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pubmed:dateCreated |
1995-2-2
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pubmed:abstractText |
Pax-3 is a member of the Pax family of transcription factors involved in transcriptional control events during embryonic development. Here we report a functional dissection of the Pax-3 protein and describe the protein domains which are responsible for different activities. A transcription inhibition activity is located in the first 90 N-terminal amino acids and includes part of the paired domain. Furthermore, the C terminus of Pax-3 is able to confer transcriptional activation of basal promoters. Pax-3 can utilize both transcription modulating functions and activates transcription over a narrow range of protein concentration in the presence of promoter elements containing functional binding sites.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-1303193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-1303207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-1347148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-1347149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-1347944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-1682057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-1821845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-1889089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-2022185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-2045114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-2196723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-2302733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-2325642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-2501086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-2504497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-2798115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-2830022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-3050531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-3548776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-7909605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-8065927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-8098985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-8099544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-8275086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-8406486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-8421686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7809114-8490648
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
91
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pubmed:geneSymbol |
Pax-3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
12745-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7809114-Amino Acid Sequence,
pubmed-meshheading:7809114-Animals,
pubmed-meshheading:7809114-Base Sequence,
pubmed-meshheading:7809114-Binding Sites,
pubmed-meshheading:7809114-Cell Adhesion Molecules, Neuronal,
pubmed-meshheading:7809114-DNA Mutational Analysis,
pubmed-meshheading:7809114-DNA-Binding Proteins,
pubmed-meshheading:7809114-Gene Expression Regulation,
pubmed-meshheading:7809114-Homeodomain Proteins,
pubmed-meshheading:7809114-Mice,
pubmed-meshheading:7809114-Molecular Sequence Data,
pubmed-meshheading:7809114-Paired Box Transcription Factors,
pubmed-meshheading:7809114-Promoter Regions, Genetic,
pubmed-meshheading:7809114-Structure-Activity Relationship,
pubmed-meshheading:7809114-Transcription, Genetic,
pubmed-meshheading:7809114-Transcription Factors,
pubmed-meshheading:7809114-Transcriptional Activation
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pubmed:year |
1994
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pubmed:articleTitle |
Pax-3 contains domains for transcription activation and transcription inhibition.
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pubmed:affiliation |
Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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