Linked Life Data

7808767

Source:http://linkedlifedata.com/resource/pubmed/id/7808767

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1995-2-1
pubmed:abstractText
Polymorphonuclear leukocytes (neutrophils) in patients with localized juvenile periodontitis with decreased chemotaxis exhibit increased adherence. The molecular basis of increased adherence of neutrophils in localized juvenile periodontitis is not clear. We show that the neutrophils from localized juvenile periodontitis patients with decreased neutrophil chemotaxis and increased adherence exhibit increased expression of the CD11/CD18 family of adherence molecules, Mac-1, leukocyte function-associated antigen (LFA-1) and p150,95, as compared with neutrophils obtained from systemically and periodontally healthy controls. Treatment of neutrophils obtained from healthy subjects with sera from localized juvenile periodontitis patients resulted in an increased expression of Mac-1, leukocyte function-associated antigen and p150,95 molecules. Sera obtained from health subjects, patients with adult periodontitis or localized juvenile periodontitis patients with normal chemotaxis did not increase the expression of CD11/CD18 molecules on the neutrophils obtained from healthy subjects. The ability of localized juvenile periodontitis sera to induce expression of adherence molecules was at least partially inhibited by pretreatment of localized juvenile periodontitis sera with anti-tumor necrosis factor and anti-interleukin-1 antibodies. Furthermore, increasing concentrations of rh-tumor necrosis factor-alpha and interleukin-1 beta also induced increased expression of the Mac-1 molecule on neutrophils from localized juvenile periodontitis patients and healthy subjects. The increased expression of adherence molecules on neutrophils from localized juvenile periodontitis patients was sustained and could not be reversed by treatment of localized juvenile periodontitis neutrophils with sera obtained from healthy subjects. The upregulation of adherence molecules on neutrophils by localized juvenile periodontitis sera in these experiments emphasizes the physiologic importance of quantitatively small but biologically significant levels of cytokines in the modulation of neutrophil functions in localized juvenile periodontitis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0902-0055
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
262-71
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:7808767-Adolescent, pubmed-meshheading:7808767-Adult, pubmed-meshheading:7808767-Aggressive Periodontitis, pubmed-meshheading:7808767-Antigens, CD11, pubmed-meshheading:7808767-Antigens, CD18, pubmed-meshheading:7808767-Cell Adhesion, pubmed-meshheading:7808767-Cell Adhesion Molecules, pubmed-meshheading:7808767-Chemotaxis, Leukocyte, pubmed-meshheading:7808767-Female, pubmed-meshheading:7808767-Humans, pubmed-meshheading:7808767-Interleukin-1, pubmed-meshheading:7808767-Lymphocyte Function-Associated Antigen-1, pubmed-meshheading:7808767-Macrophage-1 Antigen, pubmed-meshheading:7808767-Male, pubmed-meshheading:7808767-Middle Aged, pubmed-meshheading:7808767-Neutrophil Activation, pubmed-meshheading:7808767-Neutrophils, pubmed-meshheading:7808767-Tumor Necrosis Factor-alpha, pubmed-meshheading:7808767-Up-Regulation
pubmed:year
1994
pubmed:articleTitle
Neutrophil function in juvenile periodontitis: induction of adherence.
pubmed:affiliation
Division of Oral Biology, University of Pittsburgh, Pennsylvania.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't