| pubmed-article:7808219 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7808219 | lifeskim:mentions | umls-concept:C1882598 | lld:lifeskim |
| pubmed-article:7808219 | lifeskim:mentions | umls-concept:C0080093 | lld:lifeskim |
| pubmed-article:7808219 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:7808219 | lifeskim:mentions | umls-concept:C1135598 | lld:lifeskim |
| pubmed-article:7808219 | lifeskim:mentions | umls-concept:C1152805 | lld:lifeskim |
| pubmed-article:7808219 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:7808219 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:7808219 | pubmed:issue | 3-4 | lld:pubmed |
| pubmed-article:7808219 | pubmed:dateCreated | 1995-2-2 | lld:pubmed |
| pubmed-article:7808219 | pubmed:abstractText | Different NMDA receptor subunits have been recently cloned. The present paper describes the developmental profile of expression of the NR-1 subunit and three NR-2 subunits (A, B, C) in the rat central nervous system. A sensitive RNase protection assay was employed to determine simultaneously the mRNA levels of these receptor subunits. We found low levels of NR-1 mRNA (comprising all different splicing isoforms) in newborn rats with a progressive increase of its expression in the following 2-3 weeks. NR-2 subunits can be regarded as 'modulatory' since their expression can produce differences in the properties of NMDA receptors. More than one NR-2 subunits can be expressed in the same brain region. NR-2A and NR-2C are concomitantly expressed in the cerebellum and during development their mRNAs increase with a similar profile from low levels in P-8 rats to maximal expression in P-21 animals. NR-2A and NR-2B are concomitantly expressed in several brain regions with a different ontogenetic profile. In the hippocampus NR-2B mRNA increases rapidly during the first week of life as compared to the NR-2A subunits which at this time is expressed to low levels indicating that NR-2B will probably be dominant in determining the NMDA properties during the first period of life. Our data can provide a molecular correlate with properties of NMDA receptors such as voltage dependent Mg2+ block and deactivation kinetics which undergo significant changes during development and have been shown to depend upon the NR-2 subunit co-expressed with the common NR-1 subunit in various brain regions. | lld:pubmed |
| pubmed-article:7808219 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7808219 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7808219 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7808219 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7808219 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7808219 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7808219 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7808219 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7808219 | pubmed:issn | 0169-328X | lld:pubmed |
| pubmed-article:7808219 | pubmed:author | pubmed-author:RacagniGG | lld:pubmed |
| pubmed-article:7808219 | pubmed:author | pubmed-author:RivaM AMA | lld:pubmed |
| pubmed-article:7808219 | pubmed:author | pubmed-author:MolteniRR | lld:pubmed |
| pubmed-article:7808219 | pubmed:author | pubmed-author:TasceddaFF | lld:pubmed |
| pubmed-article:7808219 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7808219 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:7808219 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7808219 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7808219 | pubmed:pagination | 209-16 | lld:pubmed |
| pubmed-article:7808219 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7808219 | pubmed:meshHeading | pubmed-meshheading:7808219-... | lld:pubmed |
| pubmed-article:7808219 | pubmed:meshHeading | pubmed-meshheading:7808219-... | lld:pubmed |
| pubmed-article:7808219 | pubmed:meshHeading | pubmed-meshheading:7808219-... | lld:pubmed |
| pubmed-article:7808219 | pubmed:meshHeading | pubmed-meshheading:7808219-... | lld:pubmed |
| pubmed-article:7808219 | pubmed:meshHeading | pubmed-meshheading:7808219-... | lld:pubmed |
| pubmed-article:7808219 | pubmed:meshHeading | pubmed-meshheading:7808219-... | lld:pubmed |
| pubmed-article:7808219 | pubmed:meshHeading | pubmed-meshheading:7808219-... | lld:pubmed |
| pubmed-article:7808219 | pubmed:meshHeading | pubmed-meshheading:7808219-... | lld:pubmed |
| pubmed-article:7808219 | pubmed:meshHeading | pubmed-meshheading:7808219-... | lld:pubmed |
| pubmed-article:7808219 | pubmed:meshHeading | pubmed-meshheading:7808219-... | lld:pubmed |
| pubmed-article:7808219 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7808219 | pubmed:articleTitle | Regulation of NMDA receptor subunit mRNA expression in the rat brain during postnatal development. | lld:pubmed |
| pubmed-article:7808219 | pubmed:affiliation | DIBIT, San Raffaele Hospital, Milan, Italy. | lld:pubmed |
| pubmed-article:7808219 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7808219 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7808219 | lld:pubmed |
