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rdf:type |
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lifeskim:mentions |
umls-concept:C0011305,
umls-concept:C0017262,
umls-concept:C0027882,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0086376,
umls-concept:C0162512,
umls-concept:C1171362,
umls-concept:C1515670,
umls-concept:C1552644,
umls-concept:C1711351,
umls-concept:C1823153,
umls-concept:C2349976
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pubmed:issue |
1
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|
pubmed:dateCreated |
1995-1-30
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pubmed:databankReference |
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pubmed:abstractText |
We used subtractive hybridization to isolate clones of gamma 7, a 68 residue G-protein gamma subunit. Northern blotting and in situ hybridization reveal that the gamma 7 subunit mRNA is expressed primarily in medium-sized neurons of the neostriatum and nucleus accumbens and neurons of the olfactory tubercle, and at low levels in the dentate gyrus of the hippocampal formation and laminae II-III, and V of the neocortex. The gamma 7 mRNA is translocated into dendrites of neurons in the neostriatum and the dentate gyrus of the hippocampus. gamma 7 is expressed at relatively very low concentrations in peripheral tissues. The selective pattern of gamma 7 expression within the brain is highly reminiscent of those of the striatum-enriched adenylyl cyclase ACST, dopamine receptors, and the alpha subunit of G(olf), suggesting that, in striatum, gamma 7 may be a subunit of a G(olf) alpha-containing G protein that couples dopamine receptors selectively to ACST.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0360-4012
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
39
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pubmed:geneSymbol |
Gng7,
av,
ji
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|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
108-16
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7807587-Adenylate Cyclase,
pubmed-meshheading:7807587-Amino Acid Sequence,
pubmed-meshheading:7807587-Animals,
pubmed-meshheading:7807587-Base Sequence,
pubmed-meshheading:7807587-Cell Size,
pubmed-meshheading:7807587-DNA, Complementary,
pubmed-meshheading:7807587-Dendrites,
pubmed-meshheading:7807587-Digoxigenin,
pubmed-meshheading:7807587-GTP-Binding Proteins,
pubmed-meshheading:7807587-Gene Expression Regulation,
pubmed-meshheading:7807587-Hippocampus,
pubmed-meshheading:7807587-Male,
pubmed-meshheading:7807587-Mice,
pubmed-meshheading:7807587-Molecular Sequence Data,
pubmed-meshheading:7807587-Neostriatum,
pubmed-meshheading:7807587-Nerve Tissue Proteins,
pubmed-meshheading:7807587-Neurons,
pubmed-meshheading:7807587-Nucleic Acid Hybridization,
pubmed-meshheading:7807587-Nucleus Accumbens,
pubmed-meshheading:7807587-Olfactory Pathways,
pubmed-meshheading:7807587-Organ Specificity,
pubmed-meshheading:7807587-RNA, Messenger,
pubmed-meshheading:7807587-Rats,
pubmed-meshheading:7807587-Rats, Sprague-Dawley,
pubmed-meshheading:7807587-Receptors, Dopamine,
pubmed-meshheading:7807587-Sequence Alignment,
pubmed-meshheading:7807587-Sequence Homology, Amino Acid
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pubmed:year |
1994
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pubmed:articleTitle |
G-protein gamma 7 subunit is selectively expressed in medium-sized neurons and dendrites of the rat neostriatum.
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pubmed:affiliation |
Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
