Linked Life Data

7806911

Source:http://linkedlifedata.com/resource/pubmed/id/7806911

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-2-2
pubmed:abstractText
The possible in vivo consequences of proteolytic activity found in pancreatic pseudocyst fluid was investigated experimentally using fresh vessels from rabbit and humans. Proteolytic pseudocyst fluid caused a pronounced and time-dependent decrease in breaking strength of fresh vessels. A destruction of the normal histological architecture and fragmentation of the elastic tissue of the vessel wall paralleled the mechanical findings. The proteolytic digestion was caused by the low-mol-wt fraction of the pseudocyst fluid, corresponding to free proteases. Part of this proteolysis was probably caused by pancreatic proteases, since pancreatic juice also caused a decrease in breaking strength and a destruction of the histologic architecture of the vessel wall. Proteases bound to protease inhibitors, i.e., to alpha-2-macroglobulin, had no proteolytic activity. It is concluded that the proteolytic digestion caused by proteolytic pancreatic pseudocyst fluid may well explain severe complications of pancreatic pseudocysts, like bleeding within the pseudocyst and rupture of the entire pseudocyst wall, although the proteolytic digestion is probably counteracted by a constant regeneration of the pseudocyst wall in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0169-4197
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
23-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
The proteolytic effect of pancreatic pseudocyst fluid on vessel walls.
pubmed:affiliation
Department of Surgery, Malmö General Hospital, University of Lund, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't