Linked Life Data

7805931

Source:http://linkedlifedata.com/resource/pubmed/id/7805931

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-1-30
pubmed:abstractText
A mathematical model of CD4+ lymphocyte depletion in HIV infection is used to simulate and analyse the effect of AZT treatment. In most cases, permanent administration of AZT is observed to stop the CD4+ lymphocyte count decline and to stimulate their increase up to a new steady-state level, which depends on the intensity of AZT treatment, i.e. AZT dose. Temporary administration of AZT leads only to a temporary increase in CD4+ lymphocyte count. After the treatment is terminated, the count starts to decline again. However, the resulting prolongation of patient's survival exceeds the time interval of AZT administration. Interestingly, the survival prolongation is greater, if the treatment is started at five than at two years after the infection and there is no striking increase in survival time if a dose of AZT inhibiting 75% of HIV proliferation is used instead of a lower one inducing 25% inhibition only.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0015-5500
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
103-11
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Mathematical modelling of chemotherapy in HIV infection.
pubmed:affiliation
Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Praha.
pubmed:publicationType
Journal Article