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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
4
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pubmed:dateCreated |
1995-1-31
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|
pubmed:abstractText |
Exposure of cultured cerebellar neurons to the putative metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionate (L-AP3) for 24 h produced a neurotoxic effect which was prevented by the addition of the NMDA receptor antagonist (+)-10,11-dihydro-5-methyl-5-H-dibenzo-[a,d]-cyclohepten-5,1 0-imine hydrogen maleate (MK-801). MK-801 did also reduce neurotoxicity following 72 h exposure to L-AP3 neurotoxicity in the presence of MK-801 was antagonized by glutamate. Our results suggest that metabotropic glutamate receptors may play an important role in neuronal survival by controlling NMDA receptor-dependent as well as independent pathways.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0014-2999
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
270
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
361-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7805786-6-Cyano-7-nitroquinoxaline-2,3-dione,
pubmed-meshheading:7805786-Alanine,
pubmed-meshheading:7805786-Animals,
pubmed-meshheading:7805786-Cell Survival,
pubmed-meshheading:7805786-Cells, Cultured,
pubmed-meshheading:7805786-Cerebellum,
pubmed-meshheading:7805786-Dizocilpine Maleate,
pubmed-meshheading:7805786-Neurons,
pubmed-meshheading:7805786-Rats,
pubmed-meshheading:7805786-Receptors, Metabotropic Glutamate,
pubmed-meshheading:7805786-Receptors, N-Methyl-D-Aspartate
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pubmed:year |
1994
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pubmed:articleTitle |
Two components in neurotoxicity by L-2-amino-3-phosphonopropionate in cultured cerebellar neurons.
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pubmed:affiliation |
Departamento de Bioogia Funcional, Facultad de Medicina, Universidad de Oviedo, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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