Linked Life Data

7804803

Source:http://linkedlifedata.com/resource/pubmed/id/7804803

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-1-31
pubmed:abstractText
Polymorphonuclear neutrophils (PMN) play an important role in host defense and immune surveillance. However, PMNs can be detrimental when inflammatory stimuli are excessive and can lead to uncontrolled PMN adherence to microvascular endothelium, resulting in tissue and organ injury in the critically ill. The molecular basis of PMN-endothelial adherence is dependent on two groups of adhesion molecules and their co-specific ligands: the beta 2 integrins and their counterstructures, which are members of the immunoglobulin gene superfamily; and the selectins and their carbohydrate ligands expressed on vascular mucins and other glycoproteins or glycolipids. This review characterizes the events leading to PMN-endothelial adhesion and examines a number of in vivo models in which adhesion molecule blockade has protected against injury. The role of adhesion molecules in T-lymphocyte adhesion and immune surveillance of transplant allografts is also briefly discussed. The infectious risks of adhesion molecule blockade are reviewed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1063-7389
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
545-54
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Leukocyte-endothelial interactions and organ injury: the role of adhesion molecules.
pubmed:affiliation
Department of Anesthesiology, University of Washington School of Medicine, Seattle 98104.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't