Linked Life Data

7804375

Source:http://linkedlifedata.com/resource/pubmed/id/7804375

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-2-1
pubmed:abstractText
Cyclophosphamide (CX) has been widely used as an anticancer agent, however obtaining a maximum therapeutic potential for CX has remained a challenge, for generating undesired toxic side effects to the bladder. Crocetin, a natural carotenoid has been employed in the present studies to ameliorate the bladder toxicity of CX. Interestingly, crocetin at a dose of 50 mg/kg modulated the release of chloroacteldehyde, a urotoxic metabolite of CX in the urine of mice given combined treatment. Crocetin at the same dose significantly elevated Glutathione-S-Transferase enzyme activity both in the bladder and the liver of mice treated with CX. The exact mechanism of the protective effect of crocetin is not known, presumable it may act as an antioxidant, trapping and scavenging free radicals during the detoxification process. In Sarcoma-180 tumor bearing mice, crocetin has the ability to protect against CX induced bladder toxicity without altering its antitumor activity. Our studies are important to identify antioxidant rescue agents to overcome dose-limiting toxicity of CX.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1062-8401
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
339-43
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Protective effects of crocetin on the bladder toxicity induced by cyclophosphamide.
pubmed:affiliation
University of Minnesota Medical School, Minneapolis 55455.
pubmed:publicationType
Journal Article, Comparative Study