In this study, the effect of a single preseasonal course of injection therapy on the symptoms of patients with allergic rhinitis or asthma due to pollen from the conifer, mountain cedar, was evaluated in a double-blind controlled manner. Patients treated with specific injection therapy were found to have significantly fewer symptoms than those who received placebo injections. Specific serum IgE antimountain cedar antibody decreased during the pollen season in the treated group and increased in the placebo group.