| pubmed-article:7802679 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7802679 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:7802679 | lifeskim:mentions | umls-concept:C0055966 | lld:lifeskim |
| pubmed-article:7802679 | lifeskim:mentions | umls-concept:C0175630 | lld:lifeskim |
| pubmed-article:7802679 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:7802679 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
| pubmed-article:7802679 | lifeskim:mentions | umls-concept:C1100714 | lld:lifeskim |
| pubmed-article:7802679 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7802679 | pubmed:dateCreated | 1995-1-25 | lld:pubmed |
| pubmed-article:7802679 | pubmed:abstractText | Amyloid beta (A beta) is a fibrillar component in Alzheimers' disease amyloid deposits and a soluble peptide (sA beta) normally present in body fluids. We have recently reported that the blood-brain barrier (BBB) has a capability to control cerebrovascular sequestration and transport of circulating sA beta. In this study, we examined whether two circulating amyloid-associated proteins shown to bind sA beta, apolipoproteins J (apo J) and E (apo E), can cross the BBB alone and/or complexed to a synthetic peptide homologous to a major form of sA beta, sA beta 1-40. Brain perfusion experiments in guinea pigs showed significant uptake of both apo J and sA beta 1-40-apo J complexes. In contrast, blood-brain transport of sA beta 1-40-apo E was negligible, while apo E had a limited access across the BBB, indicating that the apo E found within the brain is produced locally. It is concluded that sA beta 1-40 binding to apo J and apo E results in significant (> 100-fold) difference in brain uptake of their respective complexes. We hypothesize that in normal brain apo J facilitates sA beta transport. | lld:pubmed |
| pubmed-article:7802679 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7802679 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7802679 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7802679 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7802679 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7802679 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7802679 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7802679 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7802679 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:7802679 | pubmed:author | pubmed-author:FrangioneBB | lld:pubmed |
| pubmed-article:7802679 | pubmed:author | pubmed-author:MatsubaraEE | lld:pubmed |
| pubmed-article:7802679 | pubmed:author | pubmed-author:McCombJ GJG | lld:pubmed |
| pubmed-article:7802679 | pubmed:author | pubmed-author:WisniewskiTT | lld:pubmed |
| pubmed-article:7802679 | pubmed:author | pubmed-author:GhisoJJ | lld:pubmed |
| pubmed-article:7802679 | pubmed:author | pubmed-author:ZlokovicB VBV | lld:pubmed |
| pubmed-article:7802679 | pubmed:author | pubmed-author:MackicJ BJB | lld:pubmed |
| pubmed-article:7802679 | pubmed:author | pubmed-author:MartelC LCL | lld:pubmed |
| pubmed-article:7802679 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7802679 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:7802679 | pubmed:volume | 205 | lld:pubmed |
| pubmed-article:7802679 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7802679 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7802679 | pubmed:pagination | 1431-7 | lld:pubmed |
| pubmed-article:7802679 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:7802679 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7802679 | pubmed:articleTitle | Brain uptake of circulating apolipoproteins J and E complexed to Alzheimer's amyloid beta. | lld:pubmed |
| pubmed-article:7802679 | pubmed:affiliation | Department of Neurological Surgery, Childrens Hospital Los Angeles, USC School of Medicine 90033. | lld:pubmed |
| pubmed-article:7802679 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7802679 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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