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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1995-1-25
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pubmed:abstractText |
Effect of deficiency in endogenous arginine synthesis was studied in connection with NO synthesis and blood pressure. Rats with massive resection of small intestine were fed an arginine-free diet (AF rats) for 24 days. Control rats were pair-fed an isonitrogenous and isocaloric arginine-replete diet. AF rats lost weight by a mean of 28 g whereas control rats kept original weight. Urinary excretion of nitrate and cGMP was reduced in AF rats by about 40% after the feeding. Blood pressure became elevated by 20-25 mmHg in AF rats after the feeding. The concentrations of arginine in muscle and plasma of AF rats were reduced to 17 and 39%, respectively, of control rats. AF rats may be a novel animal model for the in vivo study of NO.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
205
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1391-8
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:7802675-Amino Acids,
pubmed-meshheading:7802675-Animals,
pubmed-meshheading:7802675-Arginine,
pubmed-meshheading:7802675-Blood Pressure,
pubmed-meshheading:7802675-Creatinine,
pubmed-meshheading:7802675-Cyclic GMP,
pubmed-meshheading:7802675-Eating,
pubmed-meshheading:7802675-Hypertension,
pubmed-meshheading:7802675-Intestine, Small,
pubmed-meshheading:7802675-Muscles,
pubmed-meshheading:7802675-Nitrates,
pubmed-meshheading:7802675-Nitric Oxide,
pubmed-meshheading:7802675-Orotic Acid,
pubmed-meshheading:7802675-Pulse,
pubmed-meshheading:7802675-Rats,
pubmed-meshheading:7802675-Rats, Sprague-Dawley,
pubmed-meshheading:7802675-Reference Values,
pubmed-meshheading:7802675-Weight Loss
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pubmed:year |
1994
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pubmed:articleTitle |
Deficiency of endogenous arginine synthesis provokes hypertension by exhausting substrate arginine for nitric oxide synthesis.
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pubmed:affiliation |
Department of Biochemistry, Kyoto Prefectural University of Medicine, Japan.
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pubmed:publicationType |
Journal Article
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