Linked Life Data

7800682

Source:http://linkedlifedata.com/resource/pubmed/id/7800682

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-1-25
pubmed:abstractText
The effects of bovine leukosis virus (BLV) on the phenotypic and functional characteristics of peripheral blood mononuclear cells were investigated. Whole blood differentials showed that persistently lymphocytotic (BLV+PL) dairy cattle had more lymphocytes and fewer neutrophils than the aleukemic seropositive (BLV+AL) or seronegative (BLV-) animals. Flow cytometric analyses of peripheral blood mononuclear cells indicated that the BLV+PL animals had more B lymphocytes, with a concomitant decrease in CD2 positive cells when compared with the BLV- group. Mononuclear cells from the BLV+AL animals also had fewer CD2 positive cells, but no differences in B lymphocytes were observed when compared with BLV- cattle. Peripheral blood mononuclear cells were used in blastogenesis assays to assess the functional ability of lymphocytes. Lymphocytes from BLV+PL animals had lower proliferative responses to concanavalin A and pokeweed mitogen when compared with cells from the BLV- or BLV+AL groups. The level of spontaneous blastogenesis in the absence of mitogenic stimulation was high for lymphocytes obtained from BLV+AL cattle. Cultures of lymphocytes obtained from BLV+PL animals produced greater amounts of interleukin-2 (IL-2) than BLV+AL and BLV- groups, although no differences were observed in the expression of IL-2 receptors. The development of uncontrolled lymphocytosis in BLV-infected cattle may result from an altered responsiveness to IL-2-regulated B-lymphocyte proliferation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0037-9727
pubmed:author
pubmed:issnType
Print
pubmed:volume
207
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
268-73
pubmed:dateRevised
2007-11-2
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Altered interleukin-2 production by lymphocyte populations from bovine leukemia virus-infected cattle.
pubmed:affiliation
Department of Veterinary Science, College of Agricultural Sciences, Pennsylvania State University, University Park 16802-3500.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't