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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1995-1-26
|
| pubmed:abstractText |
The paper describes the synthesis of 6-[4-alkylpiperazinyl-1)phenylamino]-1,2,5-thiadiazolo[3,4-h ]quinolines where methyl (Drug G-1574) and ethyl (Drug G-1569) are alkyls. The two agents are as effective as mebendazole against the larval stage of Echinococcus multilocularis infection. Drug G-1574 has been demonstrated to ensure 100% recovery of spontaneously Hymenolepis nana-infected albino mice given doses 2.5-5 times lower than the effective dose of phenasal (niclosamide).
|
| pubmed:language |
rus
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0025-8326
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
41-4
|
| pubmed:dateRevised |
2009-10-21
|
| pubmed:meshHeading |
pubmed-meshheading:7799857-Animals,
pubmed-meshheading:7799857-Anticestodal Agents,
pubmed-meshheading:7799857-Drug Evaluation, Preclinical,
pubmed-meshheading:7799857-Echinococcosis,
pubmed-meshheading:7799857-Female,
pubmed-meshheading:7799857-Hymenolepiasis,
pubmed-meshheading:7799857-Male,
pubmed-meshheading:7799857-Mebendazole,
pubmed-meshheading:7799857-Mice,
pubmed-meshheading:7799857-Niclosamide,
pubmed-meshheading:7799857-Quinolines,
pubmed-meshheading:7799857-Sigmodontinae
|
| pubmed:articleTitle |
[The search for new antiparasitic agents. 12. The synthesis and study of the anti-Echinococcus and anti-Hymenolepis activity of 6-[4-(4-alkylpiperazinyl-1)-phenylamino]-1,2,5-thiadazolo[3 ,4-h] quinolines].
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract
|