| pubmed-article:7799225 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7799225 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:7799225 | lifeskim:mentions | umls-concept:C0600251 | lld:lifeskim |
| pubmed-article:7799225 | lifeskim:mentions | umls-concept:C0014257 | lld:lifeskim |
| pubmed-article:7799225 | lifeskim:mentions | umls-concept:C1550235 | lld:lifeskim |
| pubmed-article:7799225 | lifeskim:mentions | umls-concept:C0005528 | lld:lifeskim |
| pubmed-article:7799225 | lifeskim:mentions | umls-concept:C0173022 | lld:lifeskim |
| pubmed-article:7799225 | pubmed:dateCreated | 1995-1-26 | lld:pubmed |
| pubmed-article:7799225 | pubmed:abstractText | 1. Previous work has shown that one mechanism by which blood-borne interleukin-1 alpha (IL-1) may be able to affect the central nervous system (CNS) is by direct transport into the brain across the blood-brain barrier (BBB). The BBB of the brain consists of endothelial (between blood and interstitial fluid) and ependymal (between blood and cerebrospinal fluid) barriers. Which of these barriers IL-1 can cross has not previously been investigated. At the spinal cord, which could be the site of action for some of the effects of IL-1 such as analgesia, the BBB consists only of the endothelial barrier. 2. We show here that IL-1 labelled with 125I (I-IL) is transported across the BBB of the spinal cord by a saturable system similar to the one previously described for the brain. High performance liquid chromatography (HPLC) showed that most of the material entering the spinal cord represented intact I-IL. The BBB of the spinal cord was no more leaky to radioactively labelled albumin than the BBB of the brain and was not disrupted by 50 micrograms kg-1 of IL-1. 3. Capillary depletion showed that most of the I-IL entered the parenchymal-interstitial fluid space of the spinal cord with only a modest amount being sequestered by the endothelial cells of its BBB. 4. I-IL entered the cervical, thoracic and lumbar regions of the spinal cord equally well. I-IL entering at the brain and diffusing caudally was estimated only to account for about 1% of the total radioactivity found in the spinal cord after i.v. injection.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
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| pubmed-article:7799225 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7799225 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7799225 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7799225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7799225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7799225 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7799225 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7799225 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:7799225 | pubmed:author | pubmed-author:KastinA JAJ | lld:pubmed |
| pubmed-article:7799225 | pubmed:author | pubmed-author:BanksW AWA | lld:pubmed |
| pubmed-article:7799225 | pubmed:author | pubmed-author:EhrensingC... | lld:pubmed |
| pubmed-article:7799225 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7799225 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7799225 | pubmed:volume | 479 ( Pt 2) | lld:pubmed |
| pubmed-article:7799225 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7799225 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7799225 | pubmed:pagination | 257-64 | lld:pubmed |
| pubmed-article:7799225 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:7799225 | pubmed:meshHeading | pubmed-meshheading:7799225-... | lld:pubmed |
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| pubmed-article:7799225 | pubmed:meshHeading | pubmed-meshheading:7799225-... | lld:pubmed |
| pubmed-article:7799225 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7799225 | pubmed:articleTitle | Blood-borne interleukin-1 alpha is transported across the endothelial blood-spinal cord barrier of mice. | lld:pubmed |
| pubmed-article:7799225 | pubmed:affiliation | Veterans Affairs Medical Center, New Orleans, LA 70146. | lld:pubmed |
| pubmed-article:7799225 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7799225 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7799225 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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