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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0021764,
umls-concept:C0032105,
umls-concept:C0032854,
umls-concept:C0033325,
umls-concept:C0036974,
umls-concept:C0086418,
umls-concept:C0125606,
umls-concept:C0205217,
umls-concept:C0220662,
umls-concept:C0243026,
umls-concept:C0441889,
umls-concept:C1415957,
umls-concept:C1420873,
umls-concept:C1561558
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pubmed:issue |
1
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pubmed:dateCreated |
1995-1-24
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pubmed:abstractText |
Animal study results have suggested a role in sepsis for human interleukin for DA1.a cells/leukemia inhibitory factor (HILDA/LIF). HILDA/LIF and interleukin-6 (IL-6) levels were prospectively studied by serial ELISAs in 34 septic patients. HILDA/LIF was detected in 11 of 34 patients at plasma levels of 100-37,000 pg/mL. Peak HILDA/LIF levels correlated with increased temperature and creatinine and IL-6 and with decreased arterial CO2 (P < .05). Multivariate analysis showed that shock and decreased arterial CO2 accounted for 75% of peak HILDA/LIF plasma variations (R2 = .753). Fatal outcome was most often associated with detectable HILDA/LIF (> 56 pg/mL) and peak IL-6 plasma levels > 850 pg/mL (sensitivity, 83%; specificity, 87%), but both (at respective levels of > 480 and > 850 pg/mL) were associated with fatal outcome. HILDA/LIF was detected in septic patients exhibiting shock, and its levels correlated with higher mortality and shorter survival.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1899
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
171
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
232-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7798671-APACHE,
pubmed-meshheading:7798671-Adult,
pubmed-meshheading:7798671-Aged,
pubmed-meshheading:7798671-Aged, 80 and over,
pubmed-meshheading:7798671-Analysis of Variance,
pubmed-meshheading:7798671-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:7798671-Female,
pubmed-meshheading:7798671-Growth Inhibitors,
pubmed-meshheading:7798671-Humans,
pubmed-meshheading:7798671-Interleukin-6,
pubmed-meshheading:7798671-Leukemia Inhibitory Factor,
pubmed-meshheading:7798671-Lymphokines,
pubmed-meshheading:7798671-Male,
pubmed-meshheading:7798671-Middle Aged,
pubmed-meshheading:7798671-Prognosis,
pubmed-meshheading:7798671-Shock, Septic,
pubmed-meshheading:7798671-Survival Analysis,
pubmed-meshheading:7798671-Systemic Inflammatory Response Syndrome
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pubmed:year |
1995
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pubmed:articleTitle |
Increased plasma levels of human interleukin for DA1.a cells/leukemia inhibitory factor in sepsis correlate with shock and poor prognosis.
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pubmed:affiliation |
Service de Réanimation Médicale, Laboratoire de Statistiques et d'Informatique Médicale (CHU Hôtel-Dieu), Institut National de la Santé et de la Recherche Médicale (U211), Nantes, France.
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pubmed:publicationType |
Journal Article
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