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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1995-1-24
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pubmed:abstractText |
The kinetics of the local immune response in the upper respiratory tract to parenterally administered inactivated split trivalent influenza vaccine were examined in 19 healthy subjects. Influenza virus-specific antibody-secreting cells (ASC) could be detected as early as 2 days after vaccination in peripheral blood and tonsils, with a peak at approximately 1 week after vaccination and a decline to insignificant levels after 6 weeks. Circulating ASC produced IgG, IgA, and IgM, whereas ASC in tonsils produced mainly IgA and IgM. Influenza virus-specific antibodies were predominantly IgG and IgM in serum and IgA in oral fluid; they rose after 1 week and were elevated at 6 weeks. This may indicate a secretory involvement of the anti-influenza virus response in the upper respiratory tract. Parenteral influenza vaccination induced an immediate and significant immune response in both the upper respiratory tract and peripheral blood.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1899
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
171
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
198-203
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7798664-Adolescent,
pubmed-meshheading:7798664-Adult,
pubmed-meshheading:7798664-Antibodies, Viral,
pubmed-meshheading:7798664-Antibody-Producing Cells,
pubmed-meshheading:7798664-Female,
pubmed-meshheading:7798664-Humans,
pubmed-meshheading:7798664-Immunoglobulin A,
pubmed-meshheading:7798664-Immunoglobulin G,
pubmed-meshheading:7798664-Immunoglobulin M,
pubmed-meshheading:7798664-Influenza A virus,
pubmed-meshheading:7798664-Influenza B virus,
pubmed-meshheading:7798664-Influenza Vaccines,
pubmed-meshheading:7798664-Injections, Subcutaneous,
pubmed-meshheading:7798664-Kinetics,
pubmed-meshheading:7798664-Male,
pubmed-meshheading:7798664-Palatine Tonsil,
pubmed-meshheading:7798664-Saliva,
pubmed-meshheading:7798664-Vaccination
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pubmed:year |
1995
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pubmed:articleTitle |
Parenteral influenza vaccination induces a rapid systemic and local immune response.
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pubmed:affiliation |
Department of Microbiology and Immunology, Gade Institute, University of Bergen, Norway.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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