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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1995-1-24
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pubmed:abstractText |
Intracisternal or intraarticular inoculation of rabbit recombinant interleukin (IL)-1 beta and rabbit tumor necrosis factor-alpha combined with IL-1 receptor antagonist (IL-1RA) and soluble tumor necrosis factor receptor (sTNFR), respectively, produced significantly less inflammation in rabbits than after inoculation of these cytokines alone. In contrast, when Haemophilus influenzae type b (Hib) or Hib lipooligosaccharide (LOS) was given intraarticularly with IL-1RA, sTNFR, or the combination, there was no significant or consistent modulation of synovial inflammation and cartilage proteoglycan degradation. In the experimental meningitis model, IL-1RA and sTNFR did not significantly reduce the meningeal inflammatory response associated with intracisternal inoculation of Hib LOS. These data indicate that specific cytokine inhibitors (sTNFR and IL-1RA) may not be effective in modulating inflammation induced by a broad inflammatory stimulus such as gram-negative bacteria or their products and suggest caution in using them to treat these infectious conditions in humans.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cerebrospinal Fluid Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/IL1RN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin 1 Receptor Antagonist...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Keratan Sulfate,
http://linkedlifedata.com/resource/pubmed/chemical/Lactates,
http://linkedlifedata.com/resource/pubmed/chemical/Lactic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Sialoglycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1899
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
171
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
161-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7798656-Animals,
pubmed-meshheading:7798656-Arthritis, Infectious,
pubmed-meshheading:7798656-Brain Edema,
pubmed-meshheading:7798656-Cerebrospinal Fluid Proteins,
pubmed-meshheading:7798656-Haemophilus Infections,
pubmed-meshheading:7798656-Haemophilus influenzae,
pubmed-meshheading:7798656-Humans,
pubmed-meshheading:7798656-Interleukin 1 Receptor Antagonist Protein,
pubmed-meshheading:7798656-Interleukin-1,
pubmed-meshheading:7798656-Keratan Sulfate,
pubmed-meshheading:7798656-Lactates,
pubmed-meshheading:7798656-Lactic Acid,
pubmed-meshheading:7798656-Leukocyte Count,
pubmed-meshheading:7798656-Lipopolysaccharides,
pubmed-meshheading:7798656-Male,
pubmed-meshheading:7798656-Meningitis, Haemophilus,
pubmed-meshheading:7798656-Rabbits,
pubmed-meshheading:7798656-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:7798656-Sialoglycoproteins,
pubmed-meshheading:7798656-Solubility,
pubmed-meshheading:7798656-Synovial Fluid,
pubmed-meshheading:7798656-Tumor Necrosis Factor-alpha
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pubmed:year |
1995
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pubmed:articleTitle |
Effect of interleukin-1 receptor antagonist and soluble tumor necrosis factor receptor in animal models of infection.
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pubmed:affiliation |
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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