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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1995-1-20
|
| pubmed:abstractText |
Psychosocial (sociodemographic characteristics, loss and separation and family atmosphere in childhood, recent life events) and biological (family history, DST, TRH-test) variables were investigated in 180 patients with Major Depression (MD) and Dysthymic Disorder (DD). The aim of the study was to reveal certain differences between the chronic and non-chronic course of MD and the early- and late-onset subtypes of dysthymia. When comparing the two course patterns of MD, a higher rate of malignant tumours among first-degree relatives, a greater number of long-lasting stress situations before the index depressive episode, longer duration of the previous episodes, less frequent DST nonsuppression, and a blunted TSH response to TRH were found in patients with a chronic course of MD. Several factors seem to influence the course pattern of MD, or else the chronic form represents a subgroup within MD. The late-onset dysthymics were mainly women with a low level of education, a lower suicidal tendency, normal suppression in DST, and a lack of blunted TSH responses to TRH administration during the period of double depression. The early-onset dysthymics showed a higher number of persons who had never married, who presented a more traumatic and frustrating childhood background, and who had a higher rate of DST non-suppressors and blunted TSH responses after TRH administration during the period of their double depression. Our data suggest that late-onset dysthymia might be a biologically distinct subgroup of chronic depression.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0165-0327
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
32
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1-11
|
| pubmed:dateRevised |
2009-9-28
|
| pubmed:meshHeading |
pubmed-meshheading:7798461-Adolescent,
pubmed-meshheading:7798461-Adult,
pubmed-meshheading:7798461-Child,
pubmed-meshheading:7798461-Child, Preschool,
pubmed-meshheading:7798461-Child of Impaired Parents,
pubmed-meshheading:7798461-Chronic Disease,
pubmed-meshheading:7798461-Comorbidity,
pubmed-meshheading:7798461-Delirium, Dementia, Amnestic, Cognitive Disorders,
pubmed-meshheading:7798461-Depressive Disorder,
pubmed-meshheading:7798461-Dexamethasone,
pubmed-meshheading:7798461-Educational Status,
pubmed-meshheading:7798461-Female,
pubmed-meshheading:7798461-Follow-Up Studies,
pubmed-meshheading:7798461-Humans,
pubmed-meshheading:7798461-Hydrocortisone,
pubmed-meshheading:7798461-Life Change Events,
pubmed-meshheading:7798461-Male,
pubmed-meshheading:7798461-Middle Aged,
pubmed-meshheading:7798461-Recurrence,
pubmed-meshheading:7798461-Risk Factors,
pubmed-meshheading:7798461-Sex Factors,
pubmed-meshheading:7798461-Social Environment,
pubmed-meshheading:7798461-Suicide, Attempted,
pubmed-meshheading:7798461-Thyrotropin,
pubmed-meshheading:7798461-Thyrotropin-Releasing Hormone
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
The role of psychosocial and biological variables in separating chronic and non-chronic major depression and early-late-onset dysthymia.
|
| pubmed:affiliation |
Department of Psychiatry and Clinical Psychology, Postgraduate Medical University, Budapest, Hungary.
|
| pubmed:publicationType |
Journal Article
|