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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1995-8-3
|
| pubmed:abstractText |
The bcl-2 protooncogene was initially discovered at the t(14;18) chromosomal breakpoint in follicular lymphomas. It has been demonstrated that bcl-2 protein (Bcl-2) expression blocks apoptosis and plays an important role in cell development and maturation. In the present study, Bcl-2 expression was immunohistochemically examined in 103 cases of gastric carcinoma, as well as 64 cases of non-carcinous gastric mucosa, and its correlation with apoptosis, cell proliferation and p53 immunoreactivity was investigated. Bcl-2 was detected in 18.0% of differentiated-type gastric carcinomas (9 of 50) and 7.5% of the undifferentiated type (4 of 53). In adjacent intestinal metaplastic gastric epithelium, the incidence of Bcl-2 positivity in the incomplete type (21/23, 91.3%) was significantly higher than in the complete type (23/41, 56.1%) (P < 0.04). Double immunostaining for Bcl-2 and Ki-67 clearly revealed the majority of Bcl-2-positive cancer cells to be in a nonproliferating state, although some cancer cells expressed both proteins together. Statistical assessment demonstrated that the average Ki-67 labeling index and apoptotic labeling index in Bcl-2-positive foci were significantly lower than in Bcl-2-negative foci (P < 0.0001, P < 0.0003). In addition, a significant dissociation between Bcl-2 and p53 immunoreactivity was found in cancer tissues. These results indicate that aberrant Bcl-2 expression in gastric carcinomas possibly originates from intestinal metaplastic epithelium, and suggest a possible role in tumor development and growth.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0171-5216
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
121
|
| pubmed:geneSymbol |
bcl-2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
357-63
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7797601-Adenocarcinoma,
pubmed-meshheading:7797601-Apoptosis,
pubmed-meshheading:7797601-Carcinoma,
pubmed-meshheading:7797601-Carcinoma, Signet Ring Cell,
pubmed-meshheading:7797601-Cell Division,
pubmed-meshheading:7797601-Cell Movement,
pubmed-meshheading:7797601-Gastric Mucosa,
pubmed-meshheading:7797601-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:7797601-Humans,
pubmed-meshheading:7797601-Immunoenzyme Techniques,
pubmed-meshheading:7797601-Intestinal Neoplasms,
pubmed-meshheading:7797601-Oncogene Proteins,
pubmed-meshheading:7797601-Stomach Neoplasms,
pubmed-meshheading:7797601-Tumor Suppressor Protein p53
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Bcl-2 expression and its association with cell kinetics in human gastric carcinomas and intestinal metaplasia.
|
| pubmed:affiliation |
Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan.
|
| pubmed:publicationType |
Journal Article
|