| pubmed-article:7796884 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7796884 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:7796884 | lifeskim:mentions | umls-concept:C1336564 | lld:lifeskim |
| pubmed-article:7796884 | lifeskim:mentions | umls-concept:C1704913 | lld:lifeskim |
| pubmed-article:7796884 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:7796884 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:7796884 | lifeskim:mentions | umls-concept:C0076919 | lld:lifeskim |
| pubmed-article:7796884 | lifeskim:mentions | umls-concept:C1135650 | lld:lifeskim |
| pubmed-article:7796884 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:7796884 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:7796884 | lifeskim:mentions | umls-concept:C0380154 | lld:lifeskim |
| pubmed-article:7796884 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7796884 | pubmed:dateCreated | 1995-7-28 | lld:pubmed |
| pubmed-article:7796884 | pubmed:abstractText | A temperature-sensitive (ts) mutant of the BHK21 cell line derived from golden hamsters, tsBN462 has a mutation in the gene encoding the largest subunit of the TFIID complex, TAFII250/p230/CCG1, and arrests in the G1 phase at the nonpermissive temperature, 39.5 degrees C. We found that tsBN462 cells underwent apoptosis following growth arrest at 39.5 degrees C, suggesting a role for CCG1 as a repressor of apoptosis. By electron microscopic observation, tsBN462 cells at 39.5 degrees C showed characteristic features of apoptosis. Apoptosis was not suppressed by expression of Bc1-2 or the adenovirus E1B 19 kDa protein. Cell death was suppressed completely by expression of wild-type CCG1 and partially by wild-type p53, a growth suppressor protein. Cell cycle arrest induced by p53 may help survival of tsBN462 cells at 39.5 degrees C. Apoptosis was accelerated in SV40 large T antigen-transformed tsBN462 cells at 39.5 degrees C where SV40 large T antigen formed a complex with p53, implying that the apoptosis of tsBN462 cells at 39.5 degrees C occurred in a p53-independent manner. Our results suggest that CCG1/TAFII250 is required for the expression of factors regulating apoptosis. | lld:pubmed |
| pubmed-article:7796884 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7796884 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7796884 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7796884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7796884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7796884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7796884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7796884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7796884 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7796884 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:7796884 | pubmed:issn | 0014-4827 | lld:pubmed |
| pubmed-article:7796884 | pubmed:author | pubmed-author:HashimotoSS | lld:pubmed |
| pubmed-article:7796884 | pubmed:author | pubmed-author:SekiguchiTT | lld:pubmed |
| pubmed-article:7796884 | pubmed:author | pubmed-author:NakashimaTT | lld:pubmed |
| pubmed-article:7796884 | pubmed:author | pubmed-author:ShibataYY | lld:pubmed |
| pubmed-article:7796884 | pubmed:author | pubmed-author:HayashidaTT | lld:pubmed |
| pubmed-article:7796884 | pubmed:author | pubmed-author:TsuchidaNN | lld:pubmed |
| pubmed-article:7796884 | pubmed:author | pubmed-author:HunterTT | lld:pubmed |
| pubmed-article:7796884 | pubmed:author | pubmed-author:NishimotoTT | lld:pubmed |
| pubmed-article:7796884 | pubmed:author | pubmed-author:KuraokaAA | lld:pubmed |
| pubmed-article:7796884 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7796884 | pubmed:volume | 218 | lld:pubmed |
| pubmed-article:7796884 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7796884 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7796884 | pubmed:pagination | 490-8 | lld:pubmed |
| pubmed-article:7796884 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7796884 | pubmed:meshHeading | pubmed-meshheading:7796884-... | lld:pubmed |
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| pubmed-article:7796884 | pubmed:meshHeading | pubmed-meshheading:7796884-... | lld:pubmed |
| pubmed-article:7796884 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7796884 | pubmed:articleTitle | Apoptosis is induced in BHK cells by the tsBN462/13 mutation in the CCG1/TAFII250 subunit of the TFIID basal transcription factor. | lld:pubmed |
| pubmed-article:7796884 | pubmed:affiliation | Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. | lld:pubmed |
| pubmed-article:7796884 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7796884 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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