Linked Life Data

7796640

Source:http://linkedlifedata.com/resource/pubmed/id/7796640

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-7-31
pubmed:abstractText
The effect of aging on medium erythropoietin (EPO) levels after triiodothyronine (T3, 1 nM) stimulation in vitro and on the EPO content of kidney extract were investigated. Middle (mid)-aged (17 months), adult (6 months) and young (3 months) male rats were decapitated. The kidneys were decapsulated and cut into 6 equal pieces. One sixth of the kidney was extracted by phosphate buffer before measuring the content of EPO in kidney and one sixth of the kidney was incubated in vitro with T3 (1 nM) at 37 degrees C for 30 min. The concentration of EPO in both medium and kidney extract was measured by a radioimmunoassay (RIA). The EPO content in kidney was higher (p < 0.05) in the mid-aged than in the young rats. The basal level of medium EPO was not changed by age. Only young rather than adult or mid-aged rats showed an increase of EPO secretion after T3 stimulation (p < 0.01). These data suggest that the EPO concentration in rat kidney and the action of T3 on EPO release from the kidney are age-dependent.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0304-4920
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
229-32
pubmed:dateRevised
2009-8-12
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Age-related difference in the in vitro response of erythropoietin to triiodothyronine in male rats.
pubmed:affiliation
Department of Physiology, National Yang-Ming University, Taipei, Taiwan, Republic of China.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't