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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1995-7-26
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pubmed:abstractText |
Correction of the splanchnic oxygen deficit indicated by low gastric intramucosal pH (pHi < 7.35) appears to reduce ICU mortality. Dopexamine hydrochloride is in clinical use for this purpose but its efficacy has not been fully investigated. We report the results of a prospective, randomized, placebo-controlled study with a crossover design to assess the efficacy of dopexamine in correcting low pHi. Twelve patients in whom pHi < 7.32 was detected during eight-hourly monitoring were randomized to receive either incremental dopexamine (4-6 micrograms/kg/min) with colloid or 5% dextrose for three hours prior to crossover. There was no difference in pHi between treatments despite cardiovascular effects during dopexamine infusion. There was, however, a time-related increase in pHi suggesting a beneficial effect of conventional therapy. Dopexamine hydrochloride at 4-6 micrograms/kg/min in conjunction with colloid is not a clinically useful therapy to correct the splanchnic oxygen deficit indicated by low pHi.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0310-057X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
178-82
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7793589-Adolescent,
pubmed-meshheading:7793589-Adrenergic beta-Agonists,
pubmed-meshheading:7793589-Adult,
pubmed-meshheading:7793589-Aged,
pubmed-meshheading:7793589-Colloids,
pubmed-meshheading:7793589-Cross-Over Studies,
pubmed-meshheading:7793589-Dopamine,
pubmed-meshheading:7793589-Dopamine Agonists,
pubmed-meshheading:7793589-Female,
pubmed-meshheading:7793589-Gastric Mucosa,
pubmed-meshheading:7793589-Humans,
pubmed-meshheading:7793589-Hydrogen-Ion Concentration,
pubmed-meshheading:7793589-Intensive Care,
pubmed-meshheading:7793589-Intensive Care Units,
pubmed-meshheading:7793589-Ischemia,
pubmed-meshheading:7793589-Male,
pubmed-meshheading:7793589-Middle Aged,
pubmed-meshheading:7793589-Monitoring, Physiologic,
pubmed-meshheading:7793589-Placebos,
pubmed-meshheading:7793589-Prospective Studies,
pubmed-meshheading:7793589-Splanchnic Circulation,
pubmed-meshheading:7793589-Vasodilator Agents
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pubmed:year |
1995
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pubmed:articleTitle |
Correction of splanchnic oxygen deficit in the intensive care unit: dopexamine and colloid versus placebo.
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pubmed:affiliation |
Royal Victorian Hospital, Belfast, N. Ireland.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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