Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-7-27
pubmed:abstractText
Passive transfer of anti-Yo antibody from patients with paraneoplastic cerebellar degeneration (PCD) associated with gynecological or breast carcinoma has not been successful in inducing an animal model. We used active immunization with recombinant Yo protein of four strains of mice bearing different MHC molecules: BALB/c (H-2d), C3H (H-2k), C57BL/6 (H-2b), SJL/J (H-2s). All the strains produced high anti-Yo antibody titer but none developed cerebellar ataxia or showed Purkinje cell loss. Spleen cells from the immunized mice also reacted with recombinant protein. Because C57BL/6(nu/nu) mice produce no anti-Yo antibody, mature helper T cells are required for its production. Results suggest that antibody production in peripheral blood alone is not sufficient for the development of PCD and that MHC class II molecules function in the activation of T cells to help B cells to help B cells produce antibodies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0303-8467
pubmed:author
pubmed:issnType
Print
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
95-100
pubmed:dateRevised
2009-10-14
pubmed:meshHeading
pubmed-meshheading:7788981-Animals, pubmed-meshheading:7788981-Autoantibodies, pubmed-meshheading:7788981-Autoantigens, pubmed-meshheading:7788981-B-Lymphocytes, pubmed-meshheading:7788981-Breast Neoplasms, pubmed-meshheading:7788981-Cerebellar Ataxia, pubmed-meshheading:7788981-Cerebellar Diseases, pubmed-meshheading:7788981-DNA-Binding Proteins, pubmed-meshheading:7788981-Disease Models, Animal, pubmed-meshheading:7788981-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:7788981-Female, pubmed-meshheading:7788981-Genital Neoplasms, Female, pubmed-meshheading:7788981-Immunization, Passive, pubmed-meshheading:7788981-Immunoblotting, pubmed-meshheading:7788981-Immunoenzyme Techniques, pubmed-meshheading:7788981-Lymphocyte Activation, pubmed-meshheading:7788981-Major Histocompatibility Complex, pubmed-meshheading:7788981-Mice, pubmed-meshheading:7788981-Mice, Inbred Strains, pubmed-meshheading:7788981-Mice, Nude, pubmed-meshheading:7788981-Neoplasm Proteins, pubmed-meshheading:7788981-Nerve Degeneration, pubmed-meshheading:7788981-Nerve Tissue Proteins, pubmed-meshheading:7788981-Paraneoplastic Syndromes, pubmed-meshheading:7788981-Purkinje Cells, pubmed-meshheading:7788981-Recombinant Proteins, pubmed-meshheading:7788981-T-Lymphocytes, pubmed-meshheading:7788981-T-Lymphocytes, Helper-Inducer
pubmed:year
1995
pubmed:articleTitle
Trial to establish an animal model of paraneoplastic cerebellar degeneration with anti-Yo antibody. 1. Mouse strains bearing different MHC molecules produce antibodies on immunization with recombinant Yo protein, but do not cause Purkinje cell loss.
pubmed:affiliation
Department of Neurology, Niigata University, Japan.
pubmed:publicationType
Journal Article