| pubmed-article:7788849 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7788849 | lifeskim:mentions | umls-concept:C0003062 | lld:lifeskim |
| pubmed-article:7788849 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:7788849 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:7788849 | lifeskim:mentions | umls-concept:C0521428 | lld:lifeskim |
| pubmed-article:7788849 | lifeskim:mentions | umls-concept:C0010762 | lld:lifeskim |
| pubmed-article:7788849 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7788849 | lifeskim:mentions | umls-concept:C0015272 | lld:lifeskim |
| pubmed-article:7788849 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:7788849 | lifeskim:mentions | umls-concept:C0298986 | lld:lifeskim |
| pubmed-article:7788849 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:7788849 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:7788849 | pubmed:dateCreated | 1995-7-26 | lld:pubmed |
| pubmed-article:7788849 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7788849 | pubmed:abstractText | The broad spectrum of biological responses associated with exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) is believed to be due to the alteration in expression of TCDD-inducible genes. The aim of this study was to investigate the effects of TCDD on the in vivo tissue-specific expression of the recently identified TCDD-inducible cytochrome P450 CYP1B1 [Sutter et al. (1994) J. Biol. Chem., 269, 13092-13099] in Sprague-Dawley rats. We cloned the 5.0 kb rat homolog of CYP1B1 from a TCDD-treated rat liver cDNA library and showed that the rat and human CYP1B1 predicted amino acid sequences are 80% identical. RNA hybridization analysis showed that CYP1B1 is constitutively expressed in the adrenal glands and also in the testes of untreated rats. This tissue distribution suggests that CYP1B1 may be a physiological steroid hydroxylase. Seventy-two hours post-administration of 25 micrograms/kg body wt TCDD by gavage, steady-state levels of the 5.1 kb CYP1B1 RNA were increased > 50-fold in liver, and to a lesser extent in kidneys, lung, heart and ovaries. Average CYP1B1 RNA levels were significantly higher in the kidneys and livers of TCDD-treated females than in those from similarly treated males. In contrast, no significant sex-difference was observed in the levels of CYP1A1 in these tissues in TCDD-treated animals. In Sprague-Dawley rats, TCDD is a more potent hepatocarcinogen in females than in males. The induction of CYP1B1 in TCDD rat liver may be a contributing factor to the carcinogenic action of this persistent environmental pollutant. | lld:pubmed |
| pubmed-article:7788849 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7788849 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7788849 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7788849 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7788849 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7788849 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7788849 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7788849 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7788849 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7788849 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7788849 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7788849 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:7788849 | pubmed:issn | 0143-3334 | lld:pubmed |
| pubmed-article:7788849 | pubmed:author | pubmed-author:LucierG WGW | lld:pubmed |
| pubmed-article:7788849 | pubmed:author | pubmed-author:ClarkG CGC | lld:pubmed |
| pubmed-article:7788849 | pubmed:author | pubmed-author:WalkerN JNJ | lld:pubmed |
| pubmed-article:7788849 | pubmed:author | pubmed-author:GastelJ AJA | lld:pubmed |
| pubmed-article:7788849 | pubmed:author | pubmed-author:SutterT RTR | lld:pubmed |
| pubmed-article:7788849 | pubmed:author | pubmed-author:CostaL TLT | lld:pubmed |
| pubmed-article:7788849 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7788849 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:7788849 | pubmed:geneSymbol | CYP1B1 | lld:pubmed |
| pubmed-article:7788849 | pubmed:geneSymbol | CYP1A2 | lld:pubmed |
| pubmed-article:7788849 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7788849 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7788849 | pubmed:pagination | 1319-27 | lld:pubmed |
| pubmed-article:7788849 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:7788849 | pubmed:meshHeading | pubmed-meshheading:7788849-... | lld:pubmed |
| pubmed-article:7788849 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7788849 | pubmed:articleTitle | Rat CYP1B1: an adrenal cytochrome P450 that exhibits sex-dependent expression in livers and kidneys of TCDD-treated animals. | lld:pubmed |
| pubmed-article:7788849 | pubmed:affiliation | Department of Environmental Health Sciences, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA. | lld:pubmed |
| pubmed-article:7788849 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7788849 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7788849 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7788849 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:25426 | entrezgene:pubmed | pubmed-article:7788849 | lld:entrezgene |
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