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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1976-8-23
|
| pubmed:abstractText |
Fifty patients attending a neurological outpatient clinic for Parkinson's disease were assessed by standardized methods for both physical and psychiatric symptoms. The patients then received treatment with L-dopa with carbidopa or anticholinergic drugs and/or amantadine. During the following six-month period the subjects were assessed at intervals, both physically and psychiatrically. Forty patients were followed up for the full six-month period. The severity of physical signs and affective symptoms was shown to be significantly related at several stages of the investigation. Initially, the patients showed a high psychiatric morbidity. During treatment, 22 patients developed a depressive disorder, 12 or which had a history of previous depressive episodes. By contrast, of the 11 patients who showed very few affective symptoms during follow-up, none had a history of depression. Of the 22 patients with a depressive disorder, only two were in the anticholinergic/amantadine group, compared with nine and 11 in the other groups. L-dopa was not an effective antidepressant agent. The probable relevance of the findings of the study to the management of patients with Parkinson's disease is outlined.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amantadine,
http://linkedlifedata.com/resource/pubmed/chemical/Carbidopa,
http://linkedlifedata.com/resource/pubmed/chemical/Levodopa,
http://linkedlifedata.com/resource/pubmed/chemical/Methyldopa,
http://linkedlifedata.com/resource/pubmed/chemical/Placebos,
http://linkedlifedata.com/resource/pubmed/chemical/Trihexyphenidyl
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0033-2917
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
6
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
23-33
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:778880-Aged,
pubmed-meshheading:778880-Amantadine,
pubmed-meshheading:778880-Carbidopa,
pubmed-meshheading:778880-Clinical Trials as Topic,
pubmed-meshheading:778880-Depression,
pubmed-meshheading:778880-Dose-Response Relationship, Drug,
pubmed-meshheading:778880-Drug Therapy, Combination,
pubmed-meshheading:778880-Female,
pubmed-meshheading:778880-Follow-Up Studies,
pubmed-meshheading:778880-Humans,
pubmed-meshheading:778880-Interview, Psychological,
pubmed-meshheading:778880-Levodopa,
pubmed-meshheading:778880-Male,
pubmed-meshheading:778880-Mental Status Schedule,
pubmed-meshheading:778880-Methyldopa,
pubmed-meshheading:778880-Middle Aged,
pubmed-meshheading:778880-Parkinson Disease,
pubmed-meshheading:778880-Placebos,
pubmed-meshheading:778880-Recurrence,
pubmed-meshheading:778880-Trihexyphenidyl
|
| pubmed:year |
1976
|
| pubmed:articleTitle |
Psychiatric symptoms during l-dopa therapy for Parkinson's disease and their relationship to physical disability.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial
|