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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1995-7-19
|
| pubmed:abstractText |
In order to assess the present hepatitis B immunization program in Stockholm, Sweden, 212 children of HBsAg carrier mothers were followed up 2-9 years after birth. In babies of HBeAg-positive mothers a combined passive and active immunization schedule with hepatitis B immunoglobulin (HBIG) and hepatitis B vaccine was used. Among 25 children to such mothers, 1 HBsAg carrier and 5 children with asymptomatic seroconversion were found. To newborns of HBeAg-negative/anti-HBe-negative mothers, only vaccine was given. Among 15 such children, no HBsAg carrier (but 1 child with an asymptomatic seroconversion) was found. In babies of HBeAg-negative/anti-HBe-positive mothers, immunization was withheld between 1983 and 1987. Among 90 such children, 1 HBsAg carrier and 8 asymptomatic seroconversions were detected. After 1987, newborns in this group were vaccinated whereafter 3 asymptomatic seroconversions were found among 82 children. We conclude that in low prevalence areas a screening program for HBsAg should be offered to pregnant women originating from hepatitis B endemic regions, since immunoprophylaxis gave long-term protection to most children at risk. Children born to HBeAg-positive mothers should receive vaccine in combination with HBIg, whereas for children of mothers lacking HBeAg, vaccination only seems sufficient, at least if a rapid vaccination schedule is used.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis B Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis B Surface Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis B Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis B e Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins,
http://linkedlifedata.com/resource/pubmed/chemical/hepatitis B hyperimmune globulin
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0036-5548
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
27
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7784811-Carrier State,
pubmed-meshheading:7784811-Case-Control Studies,
pubmed-meshheading:7784811-Child,
pubmed-meshheading:7784811-Child, Preschool,
pubmed-meshheading:7784811-Dose-Response Relationship, Immunologic,
pubmed-meshheading:7784811-Female,
pubmed-meshheading:7784811-Follow-Up Studies,
pubmed-meshheading:7784811-Hepatitis B,
pubmed-meshheading:7784811-Hepatitis B Antibodies,
pubmed-meshheading:7784811-Hepatitis B Surface Antigens,
pubmed-meshheading:7784811-Hepatitis B Vaccines,
pubmed-meshheading:7784811-Hepatitis B e Antigens,
pubmed-meshheading:7784811-Humans,
pubmed-meshheading:7784811-Immunization Schedule,
pubmed-meshheading:7784811-Immunoglobulins,
pubmed-meshheading:7784811-Infant,
pubmed-meshheading:7784811-Infant, Newborn,
pubmed-meshheading:7784811-Male,
pubmed-meshheading:7784811-Pregnancy,
pubmed-meshheading:7784811-Pregnancy Complications, Infectious,
pubmed-meshheading:7784811-Sweden,
pubmed-meshheading:7784811-Treatment Outcome
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Prevention of hepatitis B by immunization of the newborn infant--a long-term follow-up study in Stockholm, Sweden.
|
| pubmed:affiliation |
Department of Infectious Diseases, Karolinska Institute, Danderyd Hospital, Sweden.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|