Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1995-7-20
|
| pubmed:abstractText |
An experimental model for local administration of neuronotrophic substances at the site of peripheral nerve lesion is presented. The model consists of a subcutaneously located silicone reservoir and a connecting tube with its distal end fixed in the proximity of the severed and repaired nerve. The results of the preliminary tests of the model are presented. Sixty Sprague-Dawley rats were divided into two groups: control (saline-treated) (n = 30) and NGF-treated (n = 30). After axotomy of the sciatic nerve, an epineurial repair is performed. NGF or saline is injected daily into the subcutaneous reservoir during the first 3 weeks after axotomy and a single dose in the fourth week. The regenerated nerve observed in the NGF-treated group after four weeks of treatment presents a greater percentage of myelinated axons, thicker myeline sheaths, and more mature endoneurial layers. This experimental model provides a reliable and quantitative way to deliver neuronotrophic substances in site and at different administration rates.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0738-1085
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
71-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7783608-Animals,
pubmed-meshheading:7783608-Axons,
pubmed-meshheading:7783608-Cell Count,
pubmed-meshheading:7783608-Disease Models, Animal,
pubmed-meshheading:7783608-Drug Delivery Systems,
pubmed-meshheading:7783608-Drug Implants,
pubmed-meshheading:7783608-Equipment Design,
pubmed-meshheading:7783608-Female,
pubmed-meshheading:7783608-Instillation, Drug,
pubmed-meshheading:7783608-Intubation,
pubmed-meshheading:7783608-Microsurgery,
pubmed-meshheading:7783608-Myelin Sheath,
pubmed-meshheading:7783608-Nerve Fibers, Myelinated,
pubmed-meshheading:7783608-Nerve Growth Factors,
pubmed-meshheading:7783608-Nerve Regeneration,
pubmed-meshheading:7783608-Rats,
pubmed-meshheading:7783608-Rats, Sprague-Dawley,
pubmed-meshheading:7783608-Reproducibility of Results,
pubmed-meshheading:7783608-Sciatic Nerve,
pubmed-meshheading:7783608-Silicones,
pubmed-meshheading:7783608-Sodium Chloride
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Experimental model for local administration of nerve growth factor in microsurgical nerve reconnections.
|
| pubmed:affiliation |
Experimental Surgery Unit, Hospital Universitario del Aire, Madrid, Spain.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|